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Gene Expression Data
Assay Details
Assay
Reference: J:52418 Smyth N, et al., Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation. J Cell Biol. 1999 Jan 11;144(1):151-60
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7660925
Gene symbol: Lamc1
Gene name: laminin, gamma 1
Antibody: anti-laminin gamma1
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 3B control: embryonic day 3.5 (more )
Structure Level Pattern Image Note
TS5: inner cell mass Present 3B control
TS5: trophectoderm Present Regionally restricted 3B control Expression is in the trophectodermal basement membrane.
Specimen 3B -/-: embryonic day 3.5; Lamc1tm1Edg/Lamc1tm1Edg (more )
Structure Level Pattern Image Note
TS5: inner cell mass Present 3B -/- About one-quarter of the expanded and hatched embryos showed no immunostaining and displayed only intracellular staining.
Specimen 3C control: embryonic day 3.5 (more )
Structure Level Pattern Image Note
TS5: inner cell mass Present 3C control
TS5: trophectoderm Present Regionally restricted 3C control Expression is in the trophectodermal basement membrane.
Specimen 3C -/-: embryonic day 3.5; Lamc1tm1Edg/Lamc1tm1Edg (more )
Structure Level Pattern Image Note
TS5: inner cell mass Present 3C -/- About one-quarter of the expanded and hatched embryos showed no immunostaining and displayed only intracellular staining.
Specimen 4E: embryonic day 4.5; Lamc1tm1Edg/Lamc1+ (more )
Note: This specimen was either wild-type or heterozygous.
Structure Level Pattern Image Note
TS6: embryo Present 4E
TS6: trophectoderm Present 4E
Specimen 4J: embryonic day 4.5; Lamc1tm1Edg/Lamc1tm1Edg (more )
Structure Level Pattern Image Note
TS6: embryo Present 4J Eight out of 40 embryos did not display immunoreactivity.
Specimen 4J mother: postnatal adult; Lamc1tm1Edg/Lamc1+ (more )
Structure Level Pattern Image Note
TS28: uterus stroma Present 4J
TS28: decidua Present Regionally restricted 4J Expression is in the epithelial lining.
Specimen 5A: embryonic day 5.5; Lamc1tm1Edg/Lamc1+ (more )
Note: This specimen was either wild-type or heterozygous.
Structure Level Pattern Image Note
TS8: embryo Present 5A
Specimen 5B: embryonic day 5.5; Lamc1tm1Edg/Lamc1tm1Edg (more )
Structure Level Pattern Image Note
TS8: embryo Absent 5B
Specimen 5C: embryonic day 5.5; Lamc1tm1Edg/Lamc1tm1Edg (more )
Structure Level Pattern Image Note
TS8: embryo Absent 5C
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory