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Gene Expression Data
Assay Details
Assay
Reference: J:154534 Martinez G, et al., Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7659037
Gene symbol: Ctnnb1
Gene name: catenin beta 1
Antibody: Anti-Active-beta-Catenin (Anti-ABC) clone 8E7 (05-665)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 3G: embryonic day 13.5 (more )
Note: Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Cell Type Level Pattern Image Note
TS21: lens epithelium lens epithelial cell Present 3G Expression was detected along cell membranes with very little nuclear reactivity.
TS21: lens fiber lens fiber cell Present 3G Expression was detected along cell membranes with very little nuclear reactivity.
Specimen 3H: embryonic day 13.5; Apctm1Tno/Apctm1Tno, Tg(Cryaa-cre)10Mlr/0 (more )
Note: Conditional mutant. Fixation was either 10% neutral buffered formalin or 4% paraformaldehyde. Embedding was either in paraffin or OCT (cryosection).
Structure Cell Type Level Pattern Image Note
TS21: lens epithelium lens epithelial cell Strong 3H Increased staining was observed compared with wild type, particularly in the cytoplasm of epithelial-like cells.
TS21: lens fiber lens fiber cell Strong 3H Increased staining was observed compared with wild type, particularly in the cytoplasm of epithelial-like cells. In some lenses, distinct nuclear Ctnnb1 was also detectable, particularly in the epithelioid cells in the fiber compartment.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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