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Gene Expression Data
Assay Details
Assay
Reference: J:344641 Raju R, et al., Profiles of Wnt pathway gene expression during tooth morphogenesis. Front Physiol. 2023;14:1316635
Assay type: RNA in situ
MGI Accession ID: MGI:7646972
Gene symbol: Dkk1
Gene name: dickkopf WNT signaling pathway inhibitor 1
Probe: Mm-Dkk1 (402521)
Probe preparation: Antisense DNA
Visualized with: Fluorescence
Results
Specimen 1A3: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: upper jaw molar mesenchyme Present 1A3
Specimen 1B3: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: upper jaw molar mesenchyme Present Regionally restricted 1B3 Strong expression toward buccal cervical loop. Weaker expression towards palatal cervical loop. No expression in coronal papilla area adjacent to enamel knot.
TS23: upper jaw mesenchyme Present Regionally restricted 1B3 Enriched expression along future alveolar bone region around tooth organ.
Specimen 2A3: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: upper jaw skeleton osteocyte Strong Regionally restricted 2A3 Strong expression within osteocytes of developing bone.
Specimen 2B3: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar odontoblast Present Regionally restricted 2B3 Expression strongly localized along secretory odontoblasts layer.
Specimen 2C3: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: upper jaw molar odontoblast Present Punctate 2C3 Few areas of punctate expression in odontoblasts near Herwig's epithelial root sheath (HERS).
TS28: upper jaw skeleton osteocyte Strong Regionally restricted 2C3 Strong expression within osteocytes of developing bone.
Specimen 2D: postnatal day 0 (more )
Note: Triple labeled: magenta - Dkk1; green - Sost (assay MGI:7646971); yellow - Wnt10a (assay MGI:7646918).
Structure Level Pattern Image Note
TS27: lower jaw molar Present 2D
Specimen 2E: postnatal day 0 (more )
Note: Triple labeled: magenta - Dkk1; green - Sost (assay MGI:7646971); yellow - Wnt10a (assay MGI:7646918).
Structure Level Pattern Image Note
TS27: upper jaw incisor Present 2E
Specimen 2F: postnatal day 0 (more )
Note: Triple labeled: magenta - Dkk1; green - Sost (assay MGI:7646971); yellow - Wnt10a (assay MGI:7646918).
Structure Level Pattern Image Note
TS27: lower jaw incisor Present 2F
Specimen 3A5,A46: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: upper jaw incisor odontoblast Strong Regionally restricted 3A6 , 3A5 Intense expression in proximal odontoblasts near cervical loop.
Specimen 3B5,B6: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: upper jaw incisor Strong Regionally restricted 3B6 , 3B5 Abundant expression in proximal odontoblasts near cervical loop.
Specimen S1 Maxillary Molar E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: upper jaw primordium Ambiguous S1_maxillary E12.5 Dkk1 Expression was minimal or absent.
Specimen S1 Maxillary Molar E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: upper jaw molar dental papilla Present Regionally restricted S1_maxillary E14.5 Dkk1 Strong expression towards buccal cervical loop. Weaker expression towards palatal cervical loop. No expression in coronal papilla area adjacent to enamel knot.
Specimen S1 Maxillary Molar E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: upper jaw molar Present Regionally restricted S1_maxillary E17.5 Dkk1 Expression remained consistent in strength and localization compared to previous stages.
Specimen S1 Mandibular Molar E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: lower jaw primordium Ambiguous S1_mandibular E12.5 Dkk1 Expression was minimal or absent.
Specimen S1 Mandibular Molar E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lower jaw molar dental papilla Present Regionally restricted S1_mandibular E14.5 Dkk1 No expression in coronal papilla area adjacent to enamel knot.
Specimen S1 Mandibular Molar E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: lower jaw molar dental papilla Strong Widespread S1_mandibular E17.5 Dkk1 Strong expression throughout dental papilla.
Specimen S2 Maxillary Incisor E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: upper jaw primordium Ambiguous S2_maxillary E12.5 Dkk1 Expression was minimal or absent.
Specimen S2 Maxillary Incisor E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: upper jaw mesenchyme Present Regionally restricted S2_maxillary E13.5 Dkk1 Enriched expression along future alveolar bone regions around tooth organ.
Specimen S2 Maxillary Incisor E15.5: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: upper jaw mesenchyme Present Regionally restricted S2_maxillary E15.5 Dkk1 Enriched expression along future alveolar bone regions around tooth organ.
Specimen S2 Maxillary Incisor E17.5: embryonic day 17.5 (more )
Structure Cell Type Level Pattern Image Note
TS25: upper jaw incisor odontoblast Present Regionally restricted S2_maxillary E17.5 Dkk1 Expression localized to pre-odontoblasts and terminally differentiating odontoblasts at developing cusp tips.
TS25: upper jaw incisor preodontoblast Present Regionally restricted S2_maxillary E17.5 Dkk1 Expression localized to pre-odontoblasts and terminally differentiating odontoblasts at developing cusp tips.
Specimen S2 Mandibular Incisor E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: lower jaw primordium Ambiguous S2_mandibular E12.5 Dkk1 Expression was minimal or absent.
Specimen S2 Mandibular Incisor E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw incisor Present S2_mandibular E13.5 Dkk1
Specimen S2 Mandibular Incisor E15.5: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lower jaw mesenchyme Present Regionally restricted S2_mandibular E15.5 Dkk1 Enriched expression along future alveolar bone regions around tooth organ.
Specimen S2 Mandibular Incisor E17.5: embryonic day 17.5 (more )
Structure Cell Type Level Pattern Image Note
TS25: lower jaw incisor odontoblast Present Regionally restricted S2_mandibular E17.5 Dkk1 Expression localized to pre-odontoblasts and terminally differentiating odontoblasts at developing cusp tips.
TS25: lower jaw incisor preodontoblast Present Regionally restricted S2_mandibular E17.5 Dkk1 Expression localized to pre-odontoblasts and terminally differentiating odontoblasts at developing cusp tips.
Specimen S3D: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw mesenchyme Present Regionally restricted S3D Enriched expression along future alveolar bone regions around tooth organ.
Specimen S3H: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lower jaw molar dental papilla Present Regionally restricted S3H Strong expression towards buccal cervical loop. Weaker expression towards palatal cervical loop. No expression in coronal papilla area adjacent to enamel knot.
Specimen S4D: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: lower jaw molar odontoblast Present Regionally restricted S4D Expression localized to pre-odontoblasts and terminally differentiating odontoblasts at developing cusp tips.
Specimen S4H: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar odontoblast Present Regionally restricted S4H Expression strongly localized along secretory odontoblast layer. Diminished expression in odontoblasts at occlusal grrove region.
Specimen S4L: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: lower jaw molar odontoblast Trace Punctate S4L Few areas of punctate expression in odontoblasts near Herwig's epithelial root sheath (HERS).
TS28: lower jaw skeleton osteocyte Strong Regionally restricted S4L Strong expression within osteocytes of developing bone.
Specimen S5A E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: upper jaw molar dental papilla Present Patchy S5A E16.5 Dkk1 Patchy expression in dental papilla mesenchyme, absent in areas with intense Wnt10a expression.
Specimen S5A E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: upper jaw molar dental papilla Present Patchy S5A E17.5 Dkk1 Patchy expression in dental papilla mesenchyme, absent in areas with intense Wnt10a expression.
Specimen S5A P0: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: upper jaw molar Present S5A P0 Dkk1
Specimen S5B E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: lower jaw molar dental papilla Present Patchy S5B E16.5 Dkk1 Patchy expression in dental papilla mesenchyme, absent in areas with intense Wnt10a expression.
Specimen S5B E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: lower jaw molar dental papilla Present Patchy S5B E17.5 Dkk1 Patchy expression in dental papilla mesenchyme, absent in areas with intense Wnt10a expression.
Specimen S5B P0: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: lower jaw molar Present S5B P0 Dkk1
Specimen S6 Maxillary Incisor: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: upper jaw incisor odontoblast Present Regionally restricted S6_maxillary Dkk1 Expression strongly localized along secretory odontoblasts layer.
Specimen S6 Mandibular Incisor: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: lower jaw incisor ameloblast Present Regionally restricted S6_mandibular Dkk1 Expression strongly localized along secretory odontoblasts layer.
Specimen S7 Maxillary Molar: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: upper jaw molar Absent S7_maxillary Dkk1
Specimen S7 Mandibular Molar: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: lower jaw molar Absent S7_mandibular Dkk1
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory