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Gene Expression Data
Assay Details
Assay
Reference: J:344641 Raju R, et al., Profiles of Wnt pathway gene expression during tooth morphogenesis. Front Physiol. 2023;14:1316635
Assay type: RNA in situ
MGI Accession ID: MGI:7646971
Gene symbol: Sost
Gene name: sclerostin
Probe: Mm-Sost (410031)
Probe preparation: Antisense DNA
Visualized with: Fluorescence
Results
Specimen 1A2: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: upper jaw molar mesenchyme Present Regionally restricted 1A2 Enriched expression along future alveolar bone region around tooth organ.
Specimen 1B2: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: upper jaw molar mesenchyme Present Regionally restricted 1B2 Strong expression toward buccal cervical loop. Weaker expression towards palatal cervical loop.
TS23: upper jaw molar dental papilla Absent 1B2 No expression in coronal papilla area adjacent to enamel knot.
Specimen 2A2: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: upper jaw molar mesenchyme Strong Regionally restricted 2A2 Expression remained consistent in strength and localization compared to previous stages.
TS26: upper jaw skeleton osteocyte Strong 2A2 Strong expression within osteocytes of developing bone.
Specimen 2B2: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: upper jaw molar odontoblast Present Regionally restricted 2B2 Expression strongly localized along secretory odontoblast layer.
Specimen 2C2: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: upper jaw skeleton osteocyte Strong Regionally restricted 2C2 Strong expression within osteocytes of developing bone.
TS28: upper jaw molar epithelium Weak Regionally restricted 2C2 Lower expression exclusively present in some areas of reduced dental epithelium (RDE).
TS28: upper jaw molar odontoblast Present Punctate 2C2 Punctate expression in a few odontoblasts near Herwig's epithelial root sheath (HERS).
Specimen 2D: postnatal day 0 (more )
Note: Triple labeled: green - Sost; magenta - Dkk1 (assay MGI:7646972); yellow - Wnt10a (assay MGI:7646918).
Structure Level Pattern Image Note
TS27: lower jaw molar Present 2D
Specimen 2E: postnatal day 0 (more )
Note: Triple labeled: green - Sost; magenta - Dkk1 (assay MGI:7646972); yellow - Wnt10a (assay MGI:7646918).
Structure Level Pattern Image Note
TS27: upper jaw incisor Present 2E
Specimen 2F: postnatal day 0 (more )
Note: Triple labeled: green - Sost; magenta - Dkk1 (assay MGI:7646972); yellow - Wnt10a (assay MGI:7646918).
Structure Level Pattern Image Note
TS27: lower jaw incisor Present 2F
Specimen 3A3,A4: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: upper jaw incisor odontoblast Strong Regionally restricted 3A4 , 3A3 Intense expression in proximal odontoblasts near cervical loop.
Specimen 3B3,B4: postnatal day 14 (more )
Structure Cell Type Level Pattern Image Note
TS28: upper jaw incisor odontoblast Strong Regionally restricted 3B4 , 3B3 Abundant expression in proximal odontoblasts near cervical loop.
Specimen S1 Maxillary Molar E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: jaw primordium mesenchyme Present S1_maxillary E12.5 Sost
Specimen S1 Maxillary Molar E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: upper jaw molar dental papilla Present Regionally restricted S1_maxillary E14.5 Sost Strong expression towards buccal cervical loop. Weaker expression towards palatal cervical loop. No expression in coronal papilla area adjacent to enamel knot.
Specimen S1 Maxillary Molar E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: upper jaw molar dental papilla Present Regionally restricted S1_maxillary E17.5 Sost Expression remained consistent in strength and localization compared to previous stages.
Specimen S1 Mandibular Molar E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: jaw primordium mesenchyme Present S1_mandibular E12.5 Sost
Specimen S1 Mandibular Molar E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: lower jaw molar dental papilla Present Regionally restricted S1_mandibular E14.5 Sost Expression in dental papilla mesenchyme. No expression in coronal papilla area adjacent to enamel knot.
Specimen S1 Mandibular Molar E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: lower jaw molar dental papilla Strong Widespread S1_mandibular E17.5 Sost Strong expression throughout dental papilla.
Specimen S2 Maxillary Incisor E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: jaw primordium mesenchyme Present S2_maxillary E12.5 Sost
Specimen S2 Maxillary Incisor E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: upper jaw mesenchyme Present Regionally restricted S2_maxillary E13.5 Sost Enriched expression along future alveolar bone regions around tooth organ.
Specimen S2 Maxillary Incisor E15.5: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: upper jaw incisor mesenchyme Present Regionally restricted S2_maxillary E15.5 Sost Expression in mesenchyme closer to enamel knot region.
TS23: upper jaw mesenchyme Present Regionally restricted S2_maxillary E15.5 Sost Enriched expression along future alveolar bone regions around tooth organ.
Specimen S2 Maxillary Incisor E17.5: embryonic day 17.5 (more )
Structure Cell Type Level Pattern Image Note
TS25: upper jaw incisor odontoblast Present Regionally restricted S2_maxillary E17.5 Sost Expression localized to pre-odontoblasts and terminally differentiating odontoblasts at developing cusp tips.
Specimen S2 Mandibular Incisor E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: jaw primordium mesenchyme Present S2_mandibular E12.5 Sost
Specimen S2 Mandibular Incisor E13.5: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw incisor Present S2_mandibular E13.5 Sost
Specimen S2 Mandibular Incisor E15.5: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lower jaw mesenchyme Present Regionally restricted S2_mandibular E15.5 Sost Enriched expression along future alveolar bone regions around tooth organ.
Specimen S2 Mandibular Incisor E17.5: embryonic day 17.5 (more )
Structure Cell Type Level Pattern Image Note
TS25: lower jaw incisor odontoblast Present Regionally restricted S2_mandibular E17.5 Sost Expression localized to pre-odontoblasts and terminally differentiating odontoblasts at developing cusp tips.
TS25: lower jaw incisor preodontoblast Present Regionally restricted S2_mandibular E17.5 Sost Expression localized to pre-odontoblasts and terminally differentiating odontoblasts at developing cusp tips.
Specimen S3C: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lower jaw molar mesenchyme Present Regionally restricted S3C Enriched expression along future alveolar bone regions around tooth organ.
Specimen S3G: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lower jaw molar Present Regionally restricted S3G Strong expression towards buccal cervical loop. Weaker expression towards palatal cervical loop. No expression in coronal papilla area adjacent to enamel knot.
Specimen S4C: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: lower jaw molar odontoblast Present Regionally restricted S4C Expression localized to pre-odontoblasts and terminally differentiating odontoblasts at developing cusp tips.
TS26: lower jaw molar preodontoblast Present Regionally restricted S4C Expression localized to pre-odontoblasts and terminally differentiating odontoblasts at developing cusp tips.
TS26: lower jaw molar dental papilla Present Patchy S4C Patchy expression in dental papilla mesenchyme, absent in areas with intense Wnt10a expression.
Specimen S4G: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar odontoblast Present Regionally restricted S4G Expression strongly localized along secretory odontoblast layer. Diminished expression in odontoblasts at occlusal grrove region.
TS27: lower jaw molar dental papilla Present Patchy S4G Patchy expression in dental papilla mesenchyme, absent in areas with intense Wnt10a expression.
Specimen S4K: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: lower jaw skeleton Strong Regionally restricted S4K Strong expression within osteocytes of developing bone.
TS28: lower jaw molar epithelium Weak Regionally restricted S4K Lower expression exclusively present in some areas of reduced dental epithelium (RDE) with
TS28: lower jaw molar Trace Punctate S4K Punctate expression in a few odontoblasts near Herwig's epithelial root sheath (HERS).
Specimen S5A E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: upper jaw molar dental papilla Present Patchy S5A E16.5 Sost Patchy expression in dental papilla mesenchyme, absent in areas with intense Wnt10a expression.
Specimen S5A E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: upper jaw molar dental papilla Present Patchy S5A E17.5 Sost Patchy expression in dental papilla mesenchyme, absent in areas with intense Wnt10a expression.
Specimen S5A P0: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: upper jaw molar Present S5A P0 Sost
Specimen S5B E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: lower jaw molar dental papilla Present Patchy S5B E16.5 Sost Patchy expression in dental papilla mesenchyme, absent in areas with intense Wnt10a expression.
Specimen S5B E17.5: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: lower jaw molar dental papilla Present Patchy S5B E17.5 Sost Patchy expression in dental papilla mesenchyme, absent in areas with intense Wnt10a expression.
Specimen S5B P0: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: lower jaw molar Present S5B P0 Sost
Specimen S6 Maxillary Incisor: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: upper jaw incisor Strong Regionally restricted S6_maxillary Sost Expression strongly localized along secretory odontoblasts layer.
Specimen S6 Mandibular Incisor: postnatal day 0 (more )
Structure Cell Type Level Pattern Image Note
TS27: lower jaw incisor odontoblast Strong Regionally restricted S6_mandibular Sost Expression strongly localized along secretory odontoblasts layer.
Specimen S7 Maxillary Molar: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: upper jaw molar Absent S7_maxillary Sost
Specimen S7 Mandibular Molar: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: lower jaw molar Absent S7_mandibular Sost
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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