Tg(Thy1-SNCA*)3D-37Nuber
Transgene Detail
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| Symbol: |
Tg(Thy1-SNCA*)3D-37Nuber |
| Name: |
transgene insertion 3D-37, Silke Nuber |
| MGI ID: |
MGI:7643547 |
| Synonyms: |
Tg(Thy1-SNCA*)37Dett, Thy1 3D alphaS |
| Transgene: |
Tg(Thy1-SNCA*)3D-37Nuber Location: unknown
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| Alliance: |
Tg(Thy1-SNCA*)3D-37Nuber page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Thy1-SNCA*)3D-37Nuber expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
SNCA (6622) |
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Tg(Thy1-SNCA*)3D-37Nuber expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Thy1 (MGI:98747) |
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Mutation details: Full-length human SCNA cDNA was mutagenized to carry G51D (nucleotide change: GGT to GAT in exon 3), V40D1 (nucleotide change GTT to GAT in exon 2), and V66D (nucleotide change GTA to GAT in exon 4) mutations placed under the control of the mouse Thy1 neuronal promoter.
(J:348676)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:348676 Nuber S, et al., Generation of G51D and 3D mice reveals decreased alpha-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinsons Dis. 2024;10(1) |
| All: |
1 reference(s) |
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Analysis Tools
