Tg(Thy1-SNCA*)G51DNuber
Transgene Detail
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| Symbol: |
Tg(Thy1-SNCA*)G51DNuber |
| Name: |
transgene insertion G51D, Silke Nuber |
| MGI ID: |
MGI:7643545 |
| Synonyms: |
Tg(Thy1-SNCA*)1Dett, Thy1-G51D |
| Transgene: |
Tg(Thy1-SNCA*)G51DNuber Location: unknown
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| Alliance: |
Tg(Thy1-SNCA*)G51DNuber page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Thy1-SNCA*)G51DNuber expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
SNCA (6622) |
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Tg(Thy1-SNCA*)G51DNuber expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Thy1 (MGI:98747) |
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Mutation details: Full-length human SCNA cDNA was mutagenized to carry a G51D mutation (nucleotide change: GGT to GAT in exon 3) and placed under the control of the mouse Thy1 neuronal promoter.
(J:348676)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:348676 Nuber S, et al., Generation of G51D and 3D mice reveals decreased alpha-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. NPJ Parkinsons Dis. 2024;10(1) |
| All: |
1 reference(s) |
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Analysis Tools
