Gene Expression Data
Assay Details
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Assay
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Reference:
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J:37450
Studer M, et al., Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1. Nature. 1996 Dec 19-26;384(6610):630-4
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Assay type:
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RNA in situ
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MGI Accession ID:
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MGI:7640206
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Gene symbol:
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Isl1
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Gene name:
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ISL1 transcription factor, LIM/homeodomain
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Probe:
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Isl1 probe
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Probe preparation:
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Antisense labelled with digoxigenin RNA
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Visualized with:
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Alkaline phosphatase
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Results
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Specimen
4a:
embryonic day 12.5
(more  )
Specimen
4a:
(close  )
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Genetic Background:
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involves: 129S7/SvEvBrd * C57BL/6
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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whole mount
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| Structure |
Level |
Pattern |
Image |
Note |
| TS20: facial nerve |
Present |
Regionally restricted |
4a
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Expression in facial branchiomotor neurons along midline.
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Specimen
4b:
(close )
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Genetic Background:
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involves: 129S7/SvEvBrd * C57BL/6
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Mutant Allele(s):
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Hoxb1tm2Brd/Hoxb1tm2Brd
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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whole mount
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| Structure |
Level |
Pattern |
Image |
Note |
| TS20: facial nerve |
Absent |
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4b
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Expression not detected in facial branchiomotor neurons along midline.
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Specimen
4c:
embryonic day 12.5
(more )
Specimen
4c:
(close )
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Genetic Background:
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involves: 129S7/SvEvBrd * C57BL/6
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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whole mount
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| Structure |
Level |
Pattern |
Image |
Note |
| TS20: facial nerve |
Present |
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4c
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Expression marks a distinctive posterior and lateral migration of facial motor nerve in wild type neurons.
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Specimen
4d:
(close )
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Genetic Background:
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involves: 129S7/SvEvBrd * C57BL/6
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Mutant Allele(s):
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Hoxb1tm2Brd/Hoxb1tm2Brd
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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whole mount
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| Structure |
Level |
Pattern |
Image |
Note |
| TS20: facial nerve |
Absent |
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4d
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Expression not detected in facial motor nerve.
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Specimen
4g:
embryonic day 15.5
(more )
Specimen
4g:
(close )
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Genetic Background:
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involves: 129S7/SvEvBrd * C57BL/6
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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whole mount
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Specimen
4h:
(close )
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Genetic Background:
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involves: 129S7/SvEvBrd * C57BL/6
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Mutant Allele(s):
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Hoxb1tm2Brd/Hoxb1tm2Brd
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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whole mount
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| Structure |
Level |
Pattern |
Image |
Note |
| TS23: facial nucleus |
Trace |
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4h
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Expression greatly diminished and then lost in mutant embryos. Weak expression in facial nucleus.
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