Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Lgr5em1(EGFP,-Cre/ERT2)Yil
Name:	leucine rich repeat containing G protein coupled receptor 5; endonuclease-mediated mutation 1, Omer Yilmaz
MGI ID:	MGI:7624526
Synonyms:	Lgr5-2A-EGFP-2A-CreERT2
Gene:	Lgr5  Location: Chr10:115286219-115423685 bp, - strand  Genetic Position: Chr10, 63.51 cM
Alliance:	Lgr5em1(EGFP,-Cre/ERT2)Yil page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (No functional change, Recombinase, Reporter) Mutation:    Insertion   Lgr5em1(EGFP,-Cre/ERT2)Yil expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Lgr5 (MGI:1341817)   Mutation details: Lgr5-2A-EGFP-2A-CreERT2 mice was generated by inserting P2A-EGFP-T2A-CreERT2 cassette in the endogenous Lgr5 gene locus immediately at the 5 end of the endogenous stop codon using CRISPR-Cas9 technology and zygote microinjection. (J:347568)

Activity:	Tissue activity of this recombinase allele
Driver:	Lgr5 (mouse) Summary of all recombinase alleles driven by Lgr5. Alliance mouse Lgr5 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgr5 Mutation:	57 strains or lines available

Original:	J:347568 Goto N, et al., Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury. Cell Stem Cell. 2022 Aug 4;29(8):1246-1261.e6
All:	1 reference(s)