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Gene Expression Data
Assay Details
Assay
Reference: J:67189 Shiojiri N, et al., Cell lineage analysis during liver development using the spf(ash)-heterozygous mouse. Lab Invest. 2001 Jan;81(1):17-25
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7619088
Gene symbol: Otc
Gene name: ornithine transcarbamylase
Antibody: anti-OTC
Detection system: Secondary antibody coupled to fluorescein
Results
Specimen 2C: embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: intrahepatic bile duct epithelium Present 2C Expression is in biliary epithelial cells and their progenitors.
TS23: liver hepatoblast Present 2C Expression is in hepatoblasts differentiating into hepatocytes in nonperiportal regions.
TS23: liver hematopoietic cell Absent 2C

Specimen 2F: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: intrahepatic bile duct epithelium Weak 2F Expression is in biliary epithelial cells.

Specimen 3D: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: intrahepatic bile duct epithelium Present 3D Expression is in biliary epithelial cells and their progenitors.

Specimen 3E: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: intrahepatic bile duct epithelium Weak 3E Expression is in biliary epithelial cells.

Specimen 4B: embryonic day 15.5; Otcspf-ash/Otc+ (more )
Structure Cell Type Level Pattern Image Note
TS23: liver hepatoblast Present Patchy 4B There is mosaic expression in hepatoblasts in nonperiportal regions.
TS23: intrahepatic bile duct epithelium Present Patchy 4B There is mosaic expression in periportal bile duct progenitors.
TS23: liver hematopoietic cell Absent 4B

Specimen 4D: embryonic day 17.5; Otcspf-ash/Otc+ (more )
Structure Cell Type Level Pattern Image Note
TS25: liver hepatoblast Present Patchy 4D There is mosaic expression in hepatoblasts in nonperiportal regions.
TS25: intrahepatic bile duct epithelium Present Patchy 4D There is mosaic expression in periportal bile duct progenitors.
TS25: liver hematopoietic cell Absent 4D

Specimen 5B: embryonic day 15.5; Otcspf-ash/Otc+ (more )
Structure Cell Type Level Pattern Image Note
TS23: liver hepatoblast Present Patchy 5B There is mosaic expression in hepatoblasts in nonperiportal regions.
TS23: intrahepatic bile duct epithelium Present Patchy 5B There is mosaic expression in periportal bile duct progenitors.

Specimen 5D: embryonic day 15.5; Otcspf-ash/Otc+ (more )
Structure Cell Type Level Pattern Image Note
TS23: liver hepatoblast Present Patchy 5D There is mosaic expression in hepatoblasts in nonperiportal regions.
TS23: intrahepatic bile duct epithelium Present Patchy 5D There is mosaic expression in periportal bile duct progenitors.

Specimen not shown: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: intrahepatic bile duct epithelium Absent


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory