Tg(ED-L2-IL1RN/IL1B)1Tcw
Transgene Detail
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| Symbol: |
Tg(ED-L2-IL1RN/IL1B)1Tcw |
| Name: |
transgene insertion 1, Timothy C Wang |
| MGI ID: |
MGI:7615180 |
| Synonyms: |
L2-IL-1Beta |
| Transgene: |
Tg(ED-L2-IL1RN/IL1B)1Tcw Location: unknown
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| Alliance: |
Tg(ED-L2-IL1RN/IL1B)1Tcw page
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| Strain of Origin: |
C57BL/6 x SJL
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(ED-L2-IL1RN/IL1B)1Tcw expresses
2 genes
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
IL1B (3553) |
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| human |
IL1RN (3557) |
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Tg(ED-L2-IL1RN/IL1B)1Tcw expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Epstein-Barr virus |
ED-L2 |
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Mutation details: The Epstein-Barr virus ED-L2 promoter drives the expression of a modified human IL1B cDNA. The modified human IL1B cDNA consists of the IL1RN signal sequence and a cDNA encoding for the 17 kDa mature human IL1B. Two lines were generated one with high expression and one with low expression. This is the high expression line 1.
(J:180282)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:180282 Quante M, et al., Bile Acid and inflammation activate gastric cardia stem cells in a mouse model of barrett-like metaplasia. Cancer Cell. 2012 Jan 17;21(1):36-51 |
| All: |
1 reference(s) |
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Analysis Tools
