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Gene Expression Data
Assay Details
Assay
Reference: J:286599 Song NN, et al., Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development. Development. 2020 Mar 30;147(6):dev185199
Assay type: RNA in situ
MGI Accession ID: MGI:7608298
Gene symbol: Dbh
Gene name: dopamine beta hydroxylase
Results
Specimen 1A Dbh: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: rhombomere 1 Present Regionally restricted 1A Dbh Expression in dorsal rhombomere 1.
Specimen 1A Dbh/Phox2a: embryonic day 10.5 (more )
Note: Double labeled: blue - Dbh; brown - Phox2a (assay MGI:7608327).
Structure Level Pattern Image Note
TS17: rhombomere 1 Present Regionally restricted 1A Dbh/Phox2a Expression in dorsal rhombomere 1, colocalized with Phox2a expression.
Specimen 1A Dbh/Phox2b: embryonic day 10.5 (more )
Note: Double labeled: blue - Dbh; brown - Phox2b (assay MGI:7608329).
Structure Level Pattern Image Note
TS17: rhombomere 1 Present Regionally restricted 1A Dbh/Phox2b Expression in dorsal rhombomere 1, colocalized with Phox2b expression.
Specimen 1B Dbh/Phox2a: embryonic day 12.5 (more )
Note: Double labeled: blue - Dbh; brown - Phox2a (assay MGI:7608327).
Structure Cell Type Level Pattern Image Note
TS20: pons noradrenergic neuron Present 1B Dbh/Phox2a
Specimen 1B Dbh/Phox2b: embryonic day 12.5 (more )
Note: Double labeled: blue - Dbh; brown - Phox2b (assay MGI:7608329).
Structure Cell Type Level Pattern Image Note
TS20: pons noradrenergic neuron Present 1B Dbh/Phox2b
Specimen 1B Dbh/Zc4h2: embryonic day 12.5 (more )
Note: Double labeled: blue - Dbh; brown - Zc4h2 (assay MGI:7608331).
Structure Cell Type Level Pattern Image Note
TS20: pons noradrenergic neuron Present 1B Dbh/Zc4h2
Specimen 2C Dbh Control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: rhombomere 1 Present Regionally restricted 2C Dbh Control Expression in dorsal rhombomere 1.
Specimen 2C Dbh Zc4h2 KO: embryonic day 10.5; Zc4h2em1.1Yqd/Zc4h2em1.1Yqd (more )
Structure Level Pattern Image Note
TS17: rhombomere 1 Present Regionally restricted 2C Dbh KO Expression not changed compared to control.
Specimen 2D Dbh Control: embryonic day 12.5 (more )
Structure Cell Type Level Pattern Image Note
TS20: pons noradrenergic neuron Present 2D Dbh Control
Specimen 2D Dbh Zc4h2 KO: embryonic day 12.5; Zc4h2em1.1Yqd/Zc4h2em1.1Yqd (more )
Structure Level Pattern Image Note
TS20: pons Trace 2D Dbh KO Expression significantly reduced compared to control.
Specimen 2E Dbh Control: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: locus coeruleus noradrenergic neuron Present 2E Dbh Control
Specimen 2E Dbh Zc4h2 KO: embryonic day 16.5; Zc4h2em1.1Yqd/Zc4h2em1.1Yqd (more )
Structure Level Pattern Image Note
TS24: locus coeruleus Absent 2E Dbh KO
Specimen 3A Dbh: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: rhombomere 1 Present Regionally restricted 3A Dbh Expression in dorsal rhombomere 1 overlapping with Rnf220 expression.
Specimen 3B Dbh: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: pons Present Regionally restricted 3B Dbh Expression overlapping with Rnf220 expression.
Specimen 3C Dbh: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: locus coeruleus noradrenergic neuron Present 3C Dbh
Specimen 3E Dbh Control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: rhombomere 1 Present Regionally restricted 3E Dbh Control Expression in dorsal rhombomere 1.
Specimen 3E Dbh Rnf220 KO: embryonic day 10.5; Rnf220em1.1Kust/Rnf220em1.1Kust (more )
Structure Level Pattern Image Note
TS17: rhombomere 1 Present Regionally restricted 3E Dbh KO Expression similar to that of control.
Specimen 3F Dbh Control: embryonic day 12.5 (more )
Structure Cell Type Level Pattern Image Note
TS20: pons noradrenergic neuron Present 3F Dbh Control
Specimen 3F Dbh Rnf220 IO: embryonic day 12.5; Rnf220em1.1Kust/Rnf220em1.1Kust (more )
Structure Level Pattern Image Note
TS20: pons Weak 3F Dbh KO Expression reduced compared to control.
Specimen 3H Dbh Control: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: locus coeruleus noradrenergic neuron Present 3H Dbh Control
Specimen 3H Dbh Rnf220 KO: embryonic day 16.5; Rnf220em1.1Kust/Rnf220em1.1Kust (more )
Structure Level Pattern Image Note
TS24: locus coeruleus Trace 3H Dbh KO Expression hardly detected in locus coeruleus region.
Specimen S1A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: metencephalon basal plate mantle layer Present Regionally restricted S1A Expression in presumptive locus coeruleus.
Specimen S2D Control: embryonic day 12.5 (more )
Structure Cell Type Level Pattern Image Note
TS20: pons noradrenergic neuron Present S2D Control
Specimen S2D Zc4h2+/-: embryonic day 12.5; Zc4h2em1.1Yqd/Zc4h2+ (more )
Structure Level Pattern Image Note
TS20: pons Weak S2D Zc2h2+/- Expression reduced to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory