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Gene Expression Data
Assay Details
Assay
Reference: J:150356 Jacobs FM, et al., Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons. Development. 2009 Jul;136(14):2363-73
Assay type: RNA in situ
MGI Accession ID: MGI:7596518
Gene symbol: Nr4a2
Gene name: nuclear receptor subfamily 4, group A, member 2
Probe: Nurr1 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A +/+ rostral: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 1A +/+ 1 Expressed in the mesodiencephalic dopamine neuronal field.

Specimen 1A +/+ middle: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 1A +/+ 2 Expressed in the mesodiencephalic dopamine neuronal field.

Specimen 1A +/+ caudal: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 1A +/+ 3 Expressed in the mesodiencephalic dopamine neuronal field.

Specimen 1A -/- rostral: embryonic day 14.5; Nr4a2tm1Omc/Nr4a2tm1Omc (more )
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 1A -/- 1 Truncated transcripts were still detected, showing patterning of the mesodiencephalic dopamine neuronal field except for the lateral-most population in the rostral part.

Specimen 1A -/- middle: embryonic day 14.5; Nr4a2tm1Omc/Nr4a2tm1Omc (more )
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 1A -/- 2 Truncated transcripts were still detected, showing patterning of the mesodiencephalic dopamine neuronal field except for the lateral-most population in the rostral part.

Specimen 1A -/- caudal: embryonic day 14.5; Nr4a2tm1Omc/Nr4a2tm1Omc (more )
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 1A -/- 3 Truncated transcripts were still detected, showing patterning of the mesodiencephalic dopamine neuronal field except for the lateral-most population in the rostral part.

Specimen 4A: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 4A Expressed in the mesodiencephalic dopamine neuronal field.
TS22: hypothalamus Present Regionally restricted 4A Expressed in the hypothalamic nuclei, located anterior to the mesodiencephalic dopamine neuronal field.

Specimen 5A: postnatal adult (more )
Structure Level Pattern Image Note
TS28: substantia nigra pars compacta Present 5A
TS28: ventral tegmental area Present 5A

Specimen 6A: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6A Expressed in the mesodiencephalic dopamine neuronal field.

Specimen 6A': embryonic day 14.5; Nr4a2tm1Omc/Nr4a2tm1Omc (more )
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6A' Truncated transcripts were still detected, showing patterning of the mesodiencephalic dopamine neuronal field except for the lateral-most population in the rostral part.

Specimen 6I: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6I Expressed in the mesodiencephalic dopamine neuronal field.

Specimen 6I': embryonic day 14.5; Nr4a2tm1Omc/Nr4a2tm1Omc (more )
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6I' Truncated transcripts were still detected, showing patterning of the mesodiencephalic dopamine neuronal field except for the lateral-most population in the rostral part.

Specimen 7A: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 7A Expressed in the mesodiencephalic dopamine neuronal field.

Specimen 7A': embryonic day 14.5; Pitx3ak/Pitx3ak (more )
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 7A' Expressed in the mesodiencephalic dopamine neuronal field, similar as in the wild-type.

Specimen 8K: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: thalamus Present 8K

Specimen 8O: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: hindbrain Present 8O

Specimen not shown: embryonic day 14.5; Dlk1tm1Hsul/Dlk1tm1Hsul (more )
Structure Level Pattern Image Note
TS22: hindbrain Present Similar as in the wild-type.
TS22: midbrain Present Similar as in the wild-type.
TS22: thalamus Present Similar as in the wild-type.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory