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Gene Expression Data
Assay Details
Assay
Reference: J:334252 Zapata G, et al., Generation of a mouse model of the neurodevelopmental disorder with dysmorphic facies and distal limb anomalies syndrome. Hum Mol Genet. 2022 Oct 10;31(20):3405-3421
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7595949
Gene symbol: Casp3
Gene name: caspase 3
Results
Specimen E13.5 Ctrl not shown: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cerebral cortex Present Expression in apoptotic cells
Specimen E13.5 Het not shown: embryonic day 13.5; Bptftm1.1Cwu/Bptf+ (more )
Structure Level Pattern Image Note
TS21: cerebral cortex Present Expression in apoptotic cells
Specimen E13.5 cKO not shown: embryonic day 13.5; Bptftm1.1Cwu/Bptftm1.1Cwu, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: cerebral cortex Present No signficant changes compared to control and heterozygote.
Specimen 3A Ctrl: embryonic day 15.5 (more )
Note: Double labeled: green - Casp3; red - Aif1 (assay MGI:7595951).
Structure Level Pattern Image Note
TS23: cerebral cortex ventricular layer Present 3A Ctrl
Specimen 3A Het: embryonic day 15.5; Bptftm1.1Cwu/Bptf+ (more )
Note: Double labeled: green - Casp3; red - Aif1 (assay MGI:7595951).
Structure Level Pattern Image Note
TS23: cerebral cortex ventricular layer Present 3A Het
Specimen 3A cKO: embryonic day 15.5; Bptftm1.1Cwu/Bptftm1.1Cwu, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Casp3; red - Aif1 (assay MGI:7595951).
Structure Level Pattern Image Note
TS23: cerebral cortex intermediate zone Present 3A cKO 10-fold increase in percentage of apoptotic cells within intermediate zone and cortical plate compared with control and heterozygous mice.
TS23: cortical plate Present 3A cKO 10-fold increase in percentage of apoptotic cells within intermediate zone and cortical plate compared with control and heterozygous mice.
TS23: cerebral cortex ventricular layer Present 3A cKO Expression within ventricular zone were largely unchanged compared to control.
Specimen 3D Ctrl: postnatal day 2 (more )
Note: Double labeled: green - Casp3; red - Aif1 (assay MGI:7595951).
Structure Level Pattern Image Note
TS27: neocortex Absent 3D Ctrl
Specimen 3D Het: postnatal day 2; Bptftm1.1Cwu/Bptf+ (more )
Note: Double labeled: green - Casp3; red - Aif1 (assay MGI:7595951).
Structure Level Pattern Image Note
TS27: neocortex Absent 3D Het
Specimen 3D cKO: postnatal day 2; Bptftm1.1Cwu/Bptftm1.1Cwu, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: green - Casp3; red - Aif1 (assay MGI:7595951).
Structure Level Pattern Image Note
TS27: neocortex Present 3D inset , 3D cKO Increased percentage in expressing cells remained elevated as late as P2.
Specimen P7 Ctrl not shown: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: neocortex Absent
Specimen P7 Het not shown: postnatal day 7; Bptftm1.1Cwu/Bptf+ (more )
Structure Level Pattern Image Note
TS28: neocortex Present More expressing cells in heterozygote compared to control.
Specimen P7 cKO not shown: postnatal day 7; Bptftm1.1Cwu/Bptftm1.1Cwu, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: neocortex Present More expressing cells in cKO compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/06/2026
MGI 6.24 		The Jackson Laboratory