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Gene Expression Data
Assay Details
Assay
Reference: J:209053 Hoekstra EJ, et al., Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons. Eur J Neurosci. 2013 Jan;37(1):23-32
Assay type: RNA in situ
MGI Accession ID: MGI:7595771
Gene symbol: Slc18a2
Gene name: solute carrier family 18 (vesicular monoamine), member 2
Probe: Vmat2 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 6A/I: embryonic day 14.5 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6I , 6A Expressed in the mesodiencephalic dopamine neuronal area, almost completely overlapped with the TH expression.
TS22: hindbrain Present Regionally restricted 6A Expressed in the anterior region.
Specimen 6B/J: embryonic day 14.5 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6B , 6J Expressed in the mesodiencephalic dopamine neuronal area, almost completely overlapped with the TH expression.
TS22: hindbrain Present Regionally restricted 6B Expressed in the anterior region.
Specimen 6C: embryonic day 14.5 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6C Expressed in the mesodiencephalic dopamine neuronal area, almost completely overlapped with the TH expression.
TS22: hindbrain Present Regionally restricted 6C Expressed in the anterior region.
Specimen 6D/K: embryonic day 14.5 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6K , 6D Expressed in the mesodiencephalic dopamine neuronal area, almost completely overlapped with the TH expression.
TS22: hindbrain Present Regionally restricted 6D Expressed in the anterior region.
Specimen 6E: embryonic day 14.5 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6E Expressed in the mesodiencephalic dopamine neuronal area, almost completely overlapped with the TH expression.
TS22: hindbrain Present Regionally restricted 6E Expressed in the anterior region.
Specimen 6F/L: embryonic day 14.5 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6L , 6F Expressed in the mesodiencephalic dopamine neuronal area, almost completely overlapped with the TH expression.
TS22: hindbrain Present Regionally restricted 6F Expressed in the anterior region.
Specimen 6G: embryonic day 14.5 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6G Expressed in the mesodiencephalic dopamine neuronal area, almost completely overlapped with the TH expression.
TS22: hindbrain Present Regionally restricted 6G Expressed in the anterior region.
Specimen 6H: embryonic day 14.5 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6H Expressed in the mesodiencephalic dopamine neuronal area, almost completely overlapped with the TH expression.
TS22: hindbrain Present Regionally restricted 6H Expressed in the anterior region.
Specimen 6A'/I': embryonic day 14.5; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6I' , 6A' Reduced expression in the medial region and the mesodiencephalic dopamine neuronal field compared with the wild-type.
TS22: hindbrain Present Regionally restricted 6I' , 6A' Expressed in the anterior region, similar as in the wild-type.
Specimen 6B'/J': embryonic day 14.5; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6J' , 6B' Reduced expression in the medial region and the mesodiencephalic dopamine neuronal field compared with the wild-type.
TS22: hindbrain Present Regionally restricted 6B' Expressed in the anterior region, similar as in the wild-type.
Specimen 6C': embryonic day 14.5; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6C' Reduced expression in the medial region and the mesodiencephalic dopamine neuronal field compared with the wild-type.
TS22: hindbrain Present Regionally restricted 6C' Expressed in the anterior region, similar as in the wild-type.
Specimen 6D'/K': embryonic day 14.5; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6D' , 6K' Reduced expression in the medial region and the mesodiencephalic dopamine neuronal field compared with the wild-type.
TS22: hindbrain Present Regionally restricted 6D' Expressed in the anterior region, similar as in the wild-type.
Specimen 6E': embryonic day 14.5; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6E' Reduced expression in the medial region and the mesodiencephalic dopamine neuronal field compared with the wild-type.
TS22: hindbrain Present Regionally restricted 6E' Expressed in the anterior region, similar as in the wild-type.
Specimen 6F'/L': embryonic day 14.5; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6L' , 6F' Reduced expression in the medial region and the mesodiencephalic dopamine neuronal field compared with the wild-type.
TS22: hindbrain Present Regionally restricted 6F' Expressed in the anterior region, similar as in the wild-type.
Specimen 6G': embryonic day 14.5; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6G' Reduced expression in the medial region and the mesodiencephalic dopamine neuronal field compared with the wild-type.
Specimen 6H': embryonic day 14.5; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS22: midbrain Present Regionally restricted 6H' Reduced expression in the medial region and the mesodiencephalic dopamine neuronal field compared with the wild-type.
Specimen 7A/A'/A*: postnatal day 80 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: substantia nigra pars compacta Present 7A* , 7A , 7A'
Specimen 7B/B': postnatal day 80 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: substantia nigra pars compacta Present 7B' , 7B
Specimen 7C/C': postnatal day 80 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: ventral tegmental area Present 7C , 7C'
TS28: substantia nigra pars compacta Present 7C
Specimen 7D/D': postnatal day 80 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: ventral tegmental area Present 7D , 7D'
TS28: substantia nigra pars compacta Present 7D
Specimen 7E/E'/E"/E*: postnatal day 80 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: ventral tegmental area Present 7E' , 7E , 7E*
TS28: substantia nigra pars compacta Present 7E" , 7E
Specimen 7F: postnatal day 80 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: ventral tegmental area Present 7F
Specimen 7G: postnatal day 80 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: ventral tegmental area Present 7G
Specimen 7H: postnatal day 80 (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: midbrain Present Regionally restricted 7H Expressed in the retrorubral field.
TS28: ventral tegmental area Present 7H
Specimen 7I/I'/I*: postnatal day 80; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: substantia nigra pars compacta Present 7I' , 7I* , 7I Reduced expression compared with the wild-type. The loss in rostral-lateral areas appeared to be comparable to the loss of TH protein.
Specimen 7J/J': postnatal day 80; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: substantia nigra pars compacta Present 7J' , 7J Reduced expression compared with the wild-type.
Specimen 7K/K': postnatal day 80; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: ventral tegmental area Present 7K' , 7K Reduced expression in the rostral and medial region compared with the wild-type.
TS28: substantia nigra pars compacta Present 7K Reduced expression compared with the wild-type.
Specimen 7L/L': postnatal day 80; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: ventral tegmental area Present 7L , 7L' More drastically reduced expression in the rostral and medial region compared with the wild-type.
TS28: substantia nigra pars compacta Present 7L Reduced expression compared with the wild-type.
Specimen 7M/M'/M"/M*: postnatal day 80; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: ventral tegmental area Present 7M , 7M* , 7M' More drastically reduced expression compared with the wild-type. The loss appeared more clear than the reduction in levels of TH.
TS28: substantia nigra pars compacta Present 7M" , 7M Reduced expression compared with the wild-type.
Specimen 7N: postnatal day 80; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: ventral tegmental area Present 7N Reduced expression compared with the wild-type.
Specimen 7O: postnatal day 80; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: ventral tegmental area Present 7O Reduced expression compared with the wild-type. Less affected in this most caudal region.
Specimen 7P: postnatal day 80; Lmx1adr/Lmx1adr (more )
Note: Double labeled: purple - Slc18a2; brown - Th (assay MGI:7595776).
Structure Level Pattern Image Note
TS28: midbrain Present Regionally restricted 7P Reduced expression in the retrorubral field compared with the wild-type.
TS28: ventral tegmental area Present 7P Reduced expression compared with the wild-type. Less affected in this most caudal region.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory