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Gene Expression Data
Assay Details
Assay
Reference: J:220849 Achilleos A, et al., MBTPS1/SKI-1/S1P proprotein convertase is required for ECM signaling and axial elongation during somitogenesis and vertebral development. Hum Mol Genet. 2015 May 15;24(10):2884-98
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7593915
Gene symbol: Fbn2
Gene name: fibrillin 2
Antibody: anti-FBN2 (HPA012853)
Detection system: Secondary antibody coupled to Alexa Fluor 350
Results
Specimen 3I control: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: paraxial mesenchyme Present Regionally restricted 3I control Expression in myofibrils demarcating 30 individual somites.
Specimen 3I cKO: embryonic day 10.5; Mbtps1tm1Jdh/Mbtps1tm1Jdh, Tg(Col1a1-cre)1Bek/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: paraxial mesenchyme Present Regionally restricted 3I Mtbtps1 cKO Significantly reduced number of somites compared to littermate control.
Specimen 7C: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: paraxial mesenchyme Present Regionally restricted 7C Expression in extracellular microfibrils demarcating boundaries surrounding each formed somites
TS17: unsegmented mesenchyme Absent 7C No expression in non-segmented presomitic mesoderm.
Specimen 7D: embryonic day 10.5; Mbtps1tm1Jdh/Mbtps1tm1Jdh, Tg(Col1a1-cre)1Bek/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: paraxial mesenchyme Present Regionally restricted 7D Abnormally expressed and distributed compared to control. Authors report disorganization of fibrils.
Specimen 7E: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: paraxial mesenchyme Present Regionally restricted 7E Expression surrounding each formed somites
Specimen 7F: embryonic day 11.5; Mbtps1tm1Jdh/Mbtps1tm1Jdh, Tg(Col1a1-cre)1Bek/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: paraxial mesenchyme Present Regionally restricted 7F Authors report extracellular matrix is disorganized even more.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory