Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(ITGAL-Ptprc*)dCWcr
Name:	transgene insertion dC, William C Raschke
MGI ID:	MGI:7606984
Synonyms:	Tg(ITGAL-Ptprca*)dCRasch
Transgene:	Tg(ITGAL-Ptprc*)dCWcr  Location: unknown
Alliance:	Tg(ITGAL-Ptprc*)dCWcr page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(ITGAL-Ptprc*)dCWcr expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Ptprc (MGI:97810)   Tg(ITGAL-Ptprc*)dCWcr expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Homolog in Mouse Note human ITGAL (3683) Itgal  (MGI:96606)   Mutation details: The human promoter was used to drive leukocyte-specific expression of the minigene. CD45-minigene transgenic strain deltaC (DeltaC or "dC") is supplied on the C57BL/6 background and thus expresses both the transgene-encoded CD45 and the endogenous C57BL/6 CD45. When the deltaC transgene is transferred to the CD45 knockout C57BL/6 background (JAX Strain #002725), the mice express only a truncated CD45 protein with a deleted cytosolic domain and therefore no functions conveyed by the CD45 cytosolic domain, including protein tyrosine phosphatase activity. (J:228058)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:228058 Coughlin S, et al., An extracatalytic function of CD45 in B cells is mediated by CD22. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6515-24
All:	1 reference(s)