Tg(ITGAL-Ptprca*)dCRasch
Transgene Detail
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| Symbol: |
Tg(ITGAL-Ptprca*)dCRasch |
| Name: |
transgene insertion dC, William C Raschke |
| MGI ID: |
MGI:7606984 |
| Synonyms: |
Tg(ITGAL-Ptprca*)dCWcr |
| Transgene: |
Tg(ITGAL-Ptprca*)dCRasch Location: unknown
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| Alliance: |
Tg(ITGAL-Ptprca*)dCRasch page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(ITGAL-Ptprca*)dCRasch expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Ptprc (MGI:97810) |
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Tg(ITGAL-Ptprca*)dCRasch expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Homolog in Mouse |
Note |
| human |
ITGAL (3683) |
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Mutation details: The human promoter was used to drive leukocyte-specific expression of the minigene. CD45-minigene transgenic strain deltaC (DeltaC or "dC") is supplied on the C57BL/6 background and thus expresses both the transgene-encoded CD45 and the endogenous C57BL/6 CD45. When the deltaC transgene is transferred to the CD45 knockout C57BL/6 background (JAX Strain #002725), the mice express only a truncated CD45 protein with a deleted cytosolic domain and therefore no functions conveyed by the CD45 cytosolic domain, including protein tyrosine phosphatase activity.
(J:228058)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:228058 Coughlin S, et al., An extracatalytic function of CD45 in B cells is mediated by CD22. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6515-24 |
| All: |
1 reference(s) |
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Analysis Tools
