Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Zic5tm1.1(cre/ERT2)Akg
Name:	zinc finger protein of the cerebellum 5; targeted mutation 1.1, Andrew K Groves
MGI ID:	MGI:7593739
Synonyms:	Zic5-CreER
Gene:	Zic5  Location: Chr14:122696572-122703127 bp, - strand  Genetic Position: Chr14, 65.96 cM, cytoband E5
Alliance:	Zic5tm1.1(cre/ERT2)Akg page

Germline Transmission:	Earliest citation of germline transmission: J:341534
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Zic5tm1.1(cre/ERT2)Akg expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Zic5 (MGI:1929518)   Mutation details: A construct carrying a P2A-GFP-CreER fusion protein, followed by a neomycin resistance cassette flanked by FRT sites was inserted at the start codon of Zic5 in exon 2. Founders were mated with ROSA-FLP mice to remove the neomycin-resistant cassette. (J:341534)

Activity:	Tissue activity of this recombinase allele
Driver:	Zic5 (mouse) Summary of all recombinase alleles driven by Zic5. Alliance mouse Zic5 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zic5 Mutation:	36 strains or lines available

Original:	J:341534 Thawani A, et al., The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border. Development. 2023 Oct 1;150(19):dev202047
All:	1 reference(s)