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Gene Expression Data
Assay Details
Assay
Reference: J:336871 Toonen JA, et al., A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development. PLoS One. 2016;11(5):e0156184
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7587740
Gene symbol: Adam10
Gene name: a disintegrin and metallopeptidase domain 10
Antibody: anti-ADAM10
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 1A: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: neural retinal epithelium Present Ubiquitous 1A Ubiquitous expression in ganglion cell and neuroblastic layers.

Specimen 1C: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: retina layer Present Ubiquitous 1C Ubiquitous expression in ganglion cell and neuroblastic layers.

Specimen 1E: postnatal day 0.5 (more )
Structure Level Pattern Image Note
TS27: retina ganglion cell layer Present Ubiquitous 1E Ubiquitous expression in ganglion cell layer.
TS27: retina nuclear layer Present Ubiquitous 1E Ubiquitous expression in neuroblastic layer.

Specimen 1G: postnatal day 7 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer Present 1G
TS28: retina inner plexiform layer Present 1G
TS28: retina outer plexiform layer Present 1G
TS28: neural retina photoreceptor cell Present 1G

Specimen 1I: postnatal day 28 (more )
Structure Cell Type Level Pattern Image Note
TS28: retina ganglion cell layer Present 1I
TS28: retina inner plexiform layer Present 1I
TS28: retina outer plexiform layer Present 1I
TS28: neural retina photoreceptor cell Present 1I

Specimen 3C: embryonic day 13.5; Adam10tm1Zhu/? (more )
Structure Level Pattern Image Note
TS21: neural retinal epithelium Present 3C

Specimen 3D: embryonic day 13.5; Adam10tm1Zhu/Adam10tm1Zhu, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: neural retinal epithelium Present Regionally restricted 3D Expression absent in most cells within central retina, but present in peripheral retina.

Specimen S2A: embryonic day 13.5; Adam10tm1Zhu/? (more )
Structure Level Pattern Image Note
TS21: neural retinal epithelium Present S2A

Specimen S2B: embryonic day 13.5; Adam10tm1Zhu/Adam10tm1Zhu, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: neural retinal epithelium Present Regionally restricted S2B Expression absent in most cells within central retina, but present in peripheral retina.

Specimen 3G: embryonic day 16.5; Adam10tm1Zhu/? (more )
Structure Level Pattern Image Note
TS24: neural retina Present 3G

Specimen 3H: embryonic day 16.5; Adam10tm1Zhu/Adam10tm1Zhu, Tg(Six3-cre)69Frty/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: retina Absent 3H Expression not detected.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory