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Gene Expression Data
Assay Details
Assay
Reference: J:330213 Ebeid M, et al., PRDM16 expression and function in mammalian cochlear development. Dev Dyn. 2022 Oct;251(10):1666-1683
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7581990
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2
Results
Specimen 1B E13.5: embryonic day 13.5 (more )
Note: Double labeled: red - Sox2; green - Prdm16 (assay MGI:7581970).
Structure Cell Type Level Pattern Image Note
TS21: cochlea epithelium Present Regionally restricted 1B E13.5 Expression was detected in the prosensory domain.
TS21: cochlea supporting cell of cochlea Present Regionally restricted 1B E13.5 Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen 1B E14.5: embryonic day 14.5 (more )
Note: Double labeled: red - Sox2; green - Prdm16 (assay MGI:7581970).
Structure Cell Type Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 1B E14.5 Expression was detected in the prosensory domain.
TS22: cochlea supporting cell of cochlea Present Regionally restricted 1B E14.5 Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen 1B E15.5: embryonic day 15.5 (more )
Note: Double labeled: red - Sox2; green - Prdm16 (assay MGI:7581970).
Structure Cell Type Level Pattern Image Note
TS23: cochlea epithelium Present Regionally restricted 1B E15.5 Expression was detected in the prosensory domain.
TS23: cochlea supporting cell of cochlea Present Regionally restricted 1B E15.5 Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen 1B E16.5: embryonic day 16.5 (more )
Note: Double labeled: red - Sox2; green - Prdm16 (assay MGI:7581970).
Structure Cell Type Level Pattern Image Note
TS24: organ of Corti Present 1B E16.5
TS24: cochlea supporting cell of cochlea Present Regionally restricted 1B E16.5 Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen 1B E18.5: embryonic day 18.5 (more )
Note: Double labeled: red - Sox2; green - Prdm16 (assay MGI:7581970).
Structure Cell Type Level Pattern Image Note
TS26: organ of Corti Present 1B E18.5
TS26: cochlea supporting cell of cochlea Present Regionally restricted 1B E18.5 Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen 1B P0: postnatal day 0 (more )
Note: Double labeled: red - Sox2; green - Prdm16 (assay MGI:7581970).
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti Present 1B P0
TS27: cochlea supporting cell of cochlea Present Regionally restricted 1B P0 Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen 1B P3: postnatal day 3 (more )
Note: Double labeled: red - Sox2; green - Prdm16 (assay MGI:7581970).
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti Present 1B P3
TS27: cochlea supporting cell of cochlea Present Regionally restricted 1B P3 Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen 1B P7: postnatal day 7 (more )
Note: Double labeled: red - Sox2; green - Prdm16 (assay MGI:7581970).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti Present 1B P7
TS28: cochlea supporting cell of cochlea Present Regionally restricted 1B P7 Partial overlap of expression with Prdm16 was noted in the region of inner supporting cells.
Specimen 1C: embryonic day 14.5 (more )
Note: Triple labeled: red - Sox2; white - Jag1 (assay MGI:7581992); green - Prdm16 (assay MGI:7581970).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 1C Merge , 1C Sox2 Expression was detected in the prosensory domain.
Specimen 2A Prdm16cGT/+: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Note: Double labeled: red - Sox2; green - Prdm16 (assay MGI:7581970).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 2A Prdm16cGT/+ Merge , 2A Prdm16cGT/+ Sox2 , 2A Prdm16cGT/+ left Expression was detected in the prosensory domain.
Specimen 2A Prdm16cGT/cGT: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Note: Double labeled: red - Sox2; green - Prdm16 (assay MGI:7581970).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 2A Prdm16cGT/cGT left , 2A Prdm16cGT/cGT Merge , 2A Prdm16cGT/cGT Sox2 Expression was detected in the prosensory domain.
Specimen 2C Prdm16cGT/+ Base: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Note: Triple labeled: red - Sox2; green - Myo6 (assay MGI:7581995); white - Tubb3 (assay MGI:7587712).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct supporting cell of cochlea Present Regionally restricted 2C Prdm16cGT/+ Base Expression was detected in supporting cells in the base of the cochlear duct.
Specimen 2C Prdm16cGT/cGT Base: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Note: Triple labeled: red - Sox2; green - Myo6 (assay MGI:7581995); white - Tubb3 (assay MGI:7587712).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct supporting cell of cochlea Present Regionally restricted 2C Prdm16cGT/cGT Base Expression was detected in supporting cells in the base of the cochlear duct.
Specimen 2C Prdm16cGT/+ Middle: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Note: Triple labeled: red - Sox2; green - Myo6 (assay MGI:7581995); white - Tubb3 (assay MGI:7587712).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct supporting cell of cochlea Present Regionally restricted 2C Prdm16cGT/+ Middle Expression was detected in supporting cells in the middle of the cochlear duct.
Specimen 2C Prdm16cGT/cGT Middle: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Note: Triple labeled: red - Sox2; green - Myo6 (assay MGI:7581995); white - Tubb3 (assay MGI:7587712).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct supporting cell of cochlea Present Regionally restricted 2C Prdm16cGT/cGT Middle Expression was detected in supporting cells in the middle of the cochlear duct.
Specimen 2C Prdm16cGT/+ Apex: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Note: Triple labeled: red - Sox2; green - Myo6 (assay MGI:7581995); white - Tubb3 (assay MGI:7587712).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct supporting cell of cochlea Present Regionally restricted 2C Prdm16cGT/+ Apex Expression was detected in supporting cells in the apex of the cochlear duct.
Specimen 2C Prdm16cGT/cGT Apex: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Note: Triple labeled: red - Sox2; green - Myo6 (assay MGI:7581995); white - Tubb3 (assay MGI:7587712).
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct supporting cell of cochlea Present Regionally restricted 2C Prdm16cGT/cGT Apex Expression was detected in supporting cells in the apex of the cochlear duct.
Specimen 3B Prdm16cGT/+: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium supporting cell of cochlea Present 3B Prdm16cGT/+
Specimen 3B Prdm16cGT/cGT: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium supporting cell of cochlea Present 3B Prdm16cGT/cGT
Specimen 3B Prdm16cGT/+ Base: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium supporting cell of cochlea Present Regionally restricted 3B Prdm16cGT/+ Base Expression was detected in supporting cells in the base of the cochlear duct.
Specimen 3B Prdm16cGT/cGT Base: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium supporting cell of cochlea Present Regionally restricted 3B Prdm16cGT/cGT Base Expression was detected in supporting cells in the base of the cochlear duct with no change in density relative to control.
Specimen 3B Prdm16cGT/+ Middle: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium supporting cell of cochlea Present Regionally restricted 3B Prdm16cGT/+ Middle Expression was detected in supporting cells in the middle of the cochlear duct.
Specimen 3B Prdm16cGT/cGT Middle: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium supporting cell of cochlea Present Regionally restricted 3B Prdm16cGT/cGT Middle Expression was detected in supporting cells in the middle of the cochlear duct with no change in density relative to control.
Specimen 3B Prdm16cGT/+ Apex: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium supporting cell of cochlea Present Regionally restricted 3B Prdm16cGT/+ Apex Expression was detected in supporting cells in the apex of the cochlear duct.
Specimen 3B Prdm16cGT/cGT Apex: postnatal day 0; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Structure Cell Type Level Pattern Image Note
TS27: cochlear duct epithelium supporting cell of cochlea Present Regionally restricted 3B Prdm16cGT/cGT Apex Expression was detected in supporting cells in the apex of the cochlear duct with a density around 150% relative to control.
Specimen 5A Prdm16cGT/+: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Note: Double labeled: red - Sox2; white - EdU.
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 5A Prdm16cGT/+ Sox2 , 5A Prdm16cGT/+ Merge , 5A Prdm16cGT/+ left Expression was detected in the prosensory domain in the apical turn.
Specimen 5A Prdm16cGT/cGT: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Note: Double labeled: red - Sox2; white - EdU.
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 5A Prdm16cGT/cGT left , 5A Prdm16cGT/cGT Sox2 , 5A Prdm16cGT/cGT Merge Expression was detected in the prosensory domain in the apical turn.
Specimen 5B Prdm16cGT/+: embryonic day 16.5; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Note: Double labeled: red - Sox2; white - EdU.
Structure Level Pattern Image Note
TS24: cochlea epithelium Present Regionally restricted 5B Prdm16cGT/+ Merge , 5B Prdm16cGT/+ Sox2 , 5B Prdm16cGT/+ left Expression was detected in the prosensory domain in the apical turn.
Specimen 5B Prdm16cGT/cGT: embryonic day 16.5; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Note: Double labeled: red - Sox2; white - EdU.
Structure Level Pattern Image Note
TS24: cochlea epithelium Present Regionally restricted 5B Prdm16cGT/cGT Merge , 5B Prdm16cGT/cGT left , 5B Prdm16cGT/cGT Sox2 Expression was detected in the prosensory domain in the apical turn.
Specimen 7F Prdm16cGT/+ Base: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Note: Double labeled: red - Sox2; green - Jag1 (assay MGI:7581992).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 7F Prdm16cGT/+ Base Expression was detected in the prosensory domain.
Specimen 7F Prdm16cGT/cGT Base: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Note: Double labeled: red - Sox2; green - Jag1 (assay MGI:7581992).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 7F Prdm16cGT/cGT Base Expression was detected in the prosensory domain.
Specimen 7F Prdm16cGT/+ Middle: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Note: Double labeled: red - Sox2; green - Jag1 (assay MGI:7581992).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 7F Prdm16cGT/+ Middle Expression was detected in the prosensory domain.
Specimen 7F Prdm16cGT/cGT Middle: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Note: Double labeled: red - Sox2; green - Jag1 (assay MGI:7581992).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 7F Prdm16cGT/cGT Middle Expression was detected in the prosensory domain.
Specimen 7F Prdm16cGT/+ Apex: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Note: Double labeled: red - Sox2; green - Jag1 (assay MGI:7581992).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 7F Prdm16cGT/+ Apex Expression was detected in the prosensory domain.
Specimen 7F Prdm16cGT/cGT Apex: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Note: Double labeled: red - Sox2; green - Jag1 (assay MGI:7581992).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 7F Prdm16cGT/cGT Apex Expression was detected in the prosensory domain.
Specimen 7G Prdm16cGT/+ Base: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Note: Double labeled: green - Sox2; red - Cdkn1b (assay MGI:7587786).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 7G Prdm16cGT/+ Base Merge , 7G Prdm16cGT/+ Base Sox2 Expression was detected in the prosensory domain.
Specimen 7G Prdm16cGT/cGT Base: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Note: Double labeled: green - Sox2; red - Cdkn1b (assay MGI:7587786).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 7G Prdm16cGT/cGT Base Merge , 7G Prdm16cGT/cGT Base Sox2 Expression was detected in the prosensory domain.
Specimen 7G Prdm16cGT/+ Middle: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Note: Double labeled: green - Sox2; red - Cdkn1b (assay MGI:7587786).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 7G Prdm16cGT/+ Middle Merge , 7G Prdm16cGT/+ Middle Sox2 Expression was detected in the prosensory domain.
Specimen 7G Prdm16cGT/cGT Middle: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Note: Double labeled: green - Sox2; red - Cdkn1b (assay MGI:7587786).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 7G Prdm16cGT/cGT Middle Merge , 7G Prdm16cGT/cGT Middle Sox2 Expression was detected in the prosensory domain.
Specimen 7G Prdm16cGT/+ Apex: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16+ (more )
Note: Double labeled: green - Sox2; red - Cdkn1b (assay MGI:7587786).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 7G Prdm16cGT/+ Apex Sox2 , 7G Prdm16cGT/+ Apex Merge Expression was detected in the prosensory domain.
Specimen 7G Prdm16cGT/cGT Apex: embryonic day 14.5; Prdm16Gt(OST67423)Lex/Prdm16Gt(OST67423)Lex (more )
Note: Double labeled: green - Sox2; red - Cdkn1b (assay MGI:7587786).
Structure Level Pattern Image Note
TS22: cochlea epithelium Present Regionally restricted 7G Prdm16cGT/cGT Apex Merge , 7G Prdm16cGT/cGT Apex Sox2 Expression was detected in the prosensory domain.
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