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Gene Expression Data
Assay Details
Assay
Reference: J:283328 Klimovich B, et al., Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo. Cell Cycle. 2020 Jan;19(1):109-123
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7569306
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase-3 (Asp175) (#9661)
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 3e Mdm2+/-: embryonic day 10.5; Mdm2tm1.1Mep/Mdm2+, Trp53tm1.1Thst/Trp53tm1.1Thst (more )
Structure Level Pattern Image Note
TS17: embryo Absent 3e Mdm2+/-;Trp53RR/RR
TS17: brain Absent 3e +/- (1) , 3e Mdm2+/-;Trp53RR/RR
TS17: heart Absent 3e +/- (2) , 3e Mdm2+/-;Trp53RR/RR
TS17: future spinal cord Absent 3e +/- (3) , 3e Mdm2+/-;Trp53RR/RR
TS17: somite Absent 3e +/- (4) , 3e Mdm2+/-;Trp53RR/RR
TS17: limb bud Absent 3e +/- (5) , 3e Mdm2+/-;Trp53RR/RR
TS17: embryo mesenchyme Absent 3e +/- (6) , 3e Mdm2+/-;Trp53RR/RR
Specimen 3e Mdm2-/-: embryonic day 10.5; Mdm2tm1.1Mep/Mdm2tm1.1Mep, Trp53tm1.1Thst/Trp53tm1.1Thst (more )
Structure Level Pattern Image Note
TS17: embryo Present Widespread 3e Mdm2-/-;Trp53RR/RR Authors report widespread apoptosis.
TS17: brain Present 3e -/- (1) , 3e Mdm2-/-;Trp53RR/RR Expression especially in neural tissues.
TS17: heart Ambiguous 3e -/- (2) , 3e Mdm2-/-;Trp53RR/RR
TS17: future spinal cord Present 3e Mdm2-/-;Trp53RR/RR , 3e -/- (3) Expression especially in neural tissues.
TS17: somite Trace 3e -/- (4) , 3e Mdm2-/-;Trp53RR/RR
TS17: limb bud Present 3e -/- (5) , 3e Mdm2-/-;Trp53RR/RR Expression in limb bud
TS17: embryo mesenchyme Ambiguous 3e Mdm2-/-;Trp53RR/RR , 3e -/- (6)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/24/2026
MGI 6.24 		The Jackson Laboratory