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Gene Expression Data
Assay Details
Assay
Reference: J:283328 Klimovich B, et al., Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo. Cell Cycle. 2020 Jan;19(1):109-123
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7569305
Gene symbol: Pcna
Gene name: proliferating cell nuclear antigen
Antibody: PC10
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 3c Mdm2+/-: embryonic day 10.5; Mdm2tm1.1Mep/Mdm2+, Trp53tm1.1Thst/Trp53tm1.1Thst (more )
Structure Level Pattern Image Note
TS17: embryo Present 3c Mdm2+/-;Trp53RR/RR
TS17: brain Present 3c Mdm2+/-;Trp53RR/RR , 3c +/- (1)
TS17: heart Present 3c +/- (2) , 3c Mdm2+/-;Trp53RR/RR
TS17: future spinal cord Present 3c Mdm2+/-;Trp53RR/RR , 3c +/- (3)
TS17: somite Present 3c +/- (4) , 3c Mdm2+/-;Trp53RR/RR
TS17: limb bud Present 3c Mdm2+/-;Trp53RR/RR , 3c +/- (5)
TS17: embryo mesenchyme Present 3c Mdm2+/-;Trp53RR/RR , 3c +/- (6)
Specimen 3c Mdm2-/-: embryonic day 10.5; Mdm2tm1.1Mep/Mdm2tm1.1Mep, Trp53tm1.1Thst/Trp53tm1.1Thst (more )
Structure Level Pattern Image Note
TS17: embryo Present 3c Mdm2-/-;Trp53RR/RR Authors report slight reduction in expression levels compared to controls.
TS17: brain Present 3c Mdm2-/-;Trp53RR/RR , 3c -/- (1)
TS17: heart Present 3c -/- (2) , 3c Mdm2-/-;Trp53RR/RR
TS17: future spinal cord Present 3c -/- (3) , 3c Mdm2-/-;Trp53RR/RR
TS17: somite Present 3c -/- (4) , 3c Mdm2-/-;Trp53RR/RR
TS17: limb bud Present 3c -/- (5) , 3c Mdm2-/-;Trp53RR/RR
TS17: embryo mesenchyme Present 3c Mdm2-/-;Trp53RR/RR , 3c -/- (6)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/28/2026
MGI 6.24 		The Jackson Laboratory