About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:48401 Minabe-Saegusa C, et al., Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach. Dev Growth Differ. 1998 Jun;40(3):343-53
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7567614
Gene symbol: Grem2
Gene name: gremlin 2, DAN family BMP antagonist
Reporter: lacZ
Direct Detection
Results
Specimen 2A: embryonic day 10.5; Grem2Gt1Nogu/Grem2+ (more )
Structure Level Pattern Image Note
TS17: brain Present Regionally restricted 2A Expressed in the region posterior to the midbrain.
TS17: future spinal cord Present 2A
TS17: hindbrain Present 2A
TS17: gut Present Regionally restricted 2A Expressed in a part of the digestive tract.

Specimen 2B: embryonic day 11.5; Grem2Gt1Nogu/Grem2+ (more )
Structure Level Pattern Image Note
TS19: brain Present Regionally restricted 2B Expressed in the region posterior to the midbrain.
TS19: future spinal cord Present 2B

Specimen 2C: embryonic day 12.5; Grem2Gt1Nogu/Grem2+ (more )
Structure Level Pattern Image Note
TS20: brain Strong Regionally restricted 2C Expressed in the region posterior to the midbrain.
TS20: spinal cord Strong 2C

Specimen 2D: embryonic day 13.5; Grem2Gt1Nogu/Grem2+ (more )
Structure Level Pattern Image Note
TS21: brain Present Regionally restricted 2D Decreased expression in the region posterior to the midbrain.
TS21: spinal cord Present 2D Decreased expression.

Specimen 2E: embryonic day 14.5; Grem2Gt1Nogu/Grem2+ (more )
Structure Level Pattern Image Note
TS22: dermis Present Widespread 2E Almost all over the body.

Specimen 2F: embryonic day 15.5; Grem2Gt1Nogu/Grem2+ (more )
Structure Level Pattern Image Note
TS23: dermis Present Widespread 2F Almost all over the body.

Specimen 3A: embryonic day 12.5; Grem2Gt1Nogu/Grem2+ (more )
Note: caudal spinal cord
Structure Level Pattern Image Note
TS20: spinal cord Present 3A
TS20: spinal cord floor plate Present 3A

Specimen 3B: embryonic day 11.5; Grem2Gt1Nogu/Grem2Gt1Nogu (more )
Note: Lumbar spinal cord. Double labeled: blue - Grem2 reporter; brown - Cntn2 (assay MGI:7567619).
Structure Cell Type Level Pattern Image Note
TS19: future spinal cord commissural neuron Present Regionally restricted 3B Expressed in the axons of dorsally located neurons, co-expressed with TAG1/Cntn2.
TS19: neural tube floor plate Present 3B
TS19: future spinal cord Present Regionally restricted 3B Also expressed in the ventral region in the lumbar spinal cord.

Specimen 3C: embryonic day 12.5; Grem2Gt1Nogu/Grem2Gt1Nogu (more )
Note: Lumbar spinal cord. Double labeled: blue - Grem2 reporter; brown - Cntn2 (assay MGI:7567619).
Structure Level Pattern Image Note
TS20: spinal cord Present Regionally restricted 3C Expressed around the center in terms of the dorso-ventral axis. Not co-expressed with TAG1/Cntn2.
TS20: spinal cord floor plate Present 3C


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/25/2025
MGI 6.24
The Jackson Laboratory