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Gene Expression Data
Assay Details
Assay
Reference: J:299703 Li X, et al., Inhibition of Sar1b, the Gene Implicated in Chylomicron Retention Disease, Impairs Migration and Morphogenesis of Developing Cortical Neurons. Neuroscience. 2020 Nov 21;449:228-240
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7567358
Gene symbol: Sar1b
Gene name: secretion associated Ras related GTPase 1B
Antibody: anti-Sar1b (ab155278)
Detection system: Secondary antibody
Results
Specimen 1 E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cerebral cortex ventricular layer Present 1A E12.5
TS20: cortical preplate Present 1A E12.5

Specimen 1 E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cerebral cortex ventricular layer Present 1A E14.5
TS22: cortical plate Present 1A E14.5
TS22: cerebral cortex intermediate zone Present Regionally restricted 1A E14.5 Expression is in tangentially oriented fibers.

Specimen 1 E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebral cortex intermediate zone Present Regionally restricted 1A E16.5 Expression is in tangentially oriented fibers.
TS24: cortical plate Weak 1A E16.5

Specimen 1 E18.5: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cerebral cortex intermediate zone Present Regionally restricted 1A E18.5 Expression is in tangentially oriented fibers.
TS26: cortical plate Trace 1A E18.5

Specimen 1 P0: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cerebral cortex intermediate zone Present Regionally restricted 1A P0 Expression is in tangentially oriented fibers.
TS27: cortical plate Absent 1A P0

Specimen 1B: embryonic day 14.5 (more )
Structure Cell Type Level Pattern Image Note
TS22: cortical plate neuron Present Regionally restricted 1A E14.5 , 1B E14.5 SARB1 Expression is in immature postmitotic neurons.
TS22: cerebral cortex intermediate zone neuron Present Regionally restricted 1B E14.5 SARB1 , 1A E14.5 Expression is in immature postmitotic neurons and is absent in the intermediate progenitor cells.
TS22: cerebral cortex subventricular zone radial glial cell Present Regionally restricted 1A E14.5 , 1B E14.5 SARB1 Expression is in the cytoplasm of radial glial cells.
TS22: cerebral cortex ventricular layer radial glial cell Present Regionally restricted 1A E14.5 , 1B E14.5 SARB1 Expression is in the cytoplasm of radial glial cells.

Specimen 1B CP: embryonic day 14.5 (more )
Note: Double labeled: green - Sar1b; red - Tubb3 (assay MGI:7567359).
Structure Cell Type Level Pattern Image Note
TS22: cortical plate neuron Present Regionally restricted 1B SARB1 CP , 1B CP Merge Expression is in immature postmitotic neurons.

Specimen 1B IZ: embryonic day 14.5 (more )
Note: Double labeled: green - Sar1b; red - Tubb3 (assay MGI:7567359).
Structure Cell Type Level Pattern Image Note
TS22: cerebral cortex intermediate zone neuron Present Regionally restricted 1B SARB1 IZ , 1B IZ Merge Expression is in immature postmitotic neurons.

Specimen 1B IZ/SVZ: embryonic day 14.5 (more )
Note: Double labeled: green - Sar1b; red - Eomes (assay MGI:7567360).
Structure Level Pattern Image Note
TS22: cerebral cortex intermediate zone Present Regionally restricted 1B SARB1 IZ/SVZ , 1B IZ/SVZ Merge Expression is absent in the intermediate progenitor cells.
TS22: cerebral cortex subventricular zone Present Regionally restricted 1B SARB1 IZ/SVZ , 1B IZ/SVZ Merge Expression is absent in the intermediate progenitor cells.

Specimen 1B VZ: embryonic day 14.5 (more )
Note: Double labeled: green - Sar1b; red - Nes (assay MGI:7567361).
Structure Cell Type Level Pattern Image Note
TS22: cerebral cortex subventricular zone radial glial cell Present Regionally restricted 1B VZ Merge , 1B SARB1 VZ Expression is in the cytoplasm of radial glial cells.
TS22: cerebral cortex ventricular layer radial glial cell Present Regionally restricted 1B VZ Merge , 1B SARB1 VZ Expression is in the cytoplasm of radial glial cells.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory