Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Cdkn2aem1.1(cre/ERT2)Jvd
Name:	cyclin dependent kinase inhibitor 2A; endonuclease-mediated mutation 1.1, Jan MA van Deursen
MGI ID:	MGI:7561499
Synonyms:	p16-EF/CreERT2
Gene:	Cdkn2a  Location: Chr4:89192710-89212856 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Alliance:	Cdkn2aem1.1(cre/ERT2)Jvd page

Germline Transmission:	Earliest citation of germline transmission: J:342853
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Cdkn2aem1.1(cre/ERT2)Jvd expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Cdkn2a (MGI:104738)   Mutation details: TALEN-targeting inserted the inducible recombinase fusion gene (cre/ERT2) into exon 1. Flp-mediated recombination removed the FRT-flanked selection cassette. (J:342853)

Activity:	Tissue activity of this recombinase allele
Driver:	Cdkn2a (mouse) Summary of all recombinase alleles driven by Cdkn2a. Alliance mouse Cdkn2a gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:	62 strains or lines available

Original:	J:342853 Cherry C, et al., Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies. Geroscience. 2023;45(4):2559-2587
All:	1 reference(s)