Birc2em1Haka
Endonuclease-mediated Allele Detail
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| Symbol: |
Birc2em1Haka |
| Name: |
baculoviral IAP repeat-containing 2; endonuclease-mediated mutation 1, Hamid Kashkar |
| MGI ID: |
MGI:7560637 |
| Synonyms: |
cIAP1 mutant RING, cIap1MutR |
| Gene: |
Birc2 Location: Chr9:7818228-7837065 bp, - strand Genetic Position: Chr9, 2.46 cM, cytoband A1
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| Alliance: |
Birc2em1Haka page
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| Allele Type: |
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Endonuclease-mediated (Not Applicable) |
| Mutation: |
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Intragenic deletion
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Mutation details: CRISPR/Cas9 technology generated a 13-bp deletion leading to a frameshift that shortens the protein by three amino acids introducing a premature stop codon at position 610 (T602LfsTer7). This deletion was generated by simultaneously injecting C57BL/6N zygotes with two sgRNAs targeting Birc2 (5-TCTGCAGGGGGACAATCAAG-3) and Birc3 (5-ATCTGTAGAGGGACCATCAA-3) and was generated at the same time as the Birc3em1Haka allele.
(J:342656)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Birc2 Mutation: |
31 strains or lines available
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| Original: |
J:342656 Schorn F, et al., cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. EMBO J. 2023 Nov 15;42(22):e113614 |
| All: |
1 reference(s) |
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Analysis Tools
