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Gene Expression Data
Assay Details
Assay
Reference: J:118633 Rocha-Sanchez SM, et al., Developmental expression of Kcnq4 in vestibular neurons and neurosensory epithelia. Brain Res. 2007 Mar 30;1139:117-25
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7548897
Gene symbol: Kcnq4
Gene name: potassium voltage-gated channel, subfamily Q, member 4
Antibody: anti-KCNQ4
Detection system: Secondary antibody coupled to Alexa Fluor 568
Results
Specimen 1A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: macula of utricle Trace Regionally restricted 1A Just above background levels, barely detectable in the striolar region.
Specimen 1A inset: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: macula of utricle Weak Regionally restricted 1A inset Few positive striolar hair cells were shown.
Specimen 1B: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: macula of utricle Present Regionally restricted 1B Expressed more ubiquitously in the striolar region.
Specimen 1C: postnatal day 8 (more )
Structure Level Pattern Image Note
TS28: macula of utricle Present 1C Increased expression in the striolar region.
Specimen 1D: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: macula of utricle Present Regionally restricted 1D Increased expression in the striolar region, and progressed toward the extra-striolar region.
Specimen 1E: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: macula of utricle Present 1E Increased expression in the striolar region, and progressed toward the extra-striolar region.
Specimen 1F: postnatal day 35 (more )
Structure Level Pattern Image Note
TS28: macula of utricle Present 1F Increased expression in the striolar region and the extra-striolar region.
Specimen 2B: postnatal day 8 (more )
Note: Posterior Crista.
Structure Level Pattern Image Note
TS28: crista ampullaris Present 2B , 2B inset Expression extended from the central zone hair cells to the peripheral zone.
TS28: posterior semicircular canal Present 2B , 2B inset Expression extended from the central zone hair cells to the peripheral zone.
Specimen 2C: postnatal day 21 (more )
Note: Anterior Crista.
Structure Level Pattern Image Note
TS28: crista ampullaris Present 2C Expression extended from the central zone hair cells to the peripheral zone.
Specimen 2D: postnatal day 120 (more )
Note: Anterior Crista.
Structure Level Pattern Image Note
TS28: crista ampullaris Present Widespread 2D Expression extended to the entire sensory epithelium.
Specimen 3A/C: postnatal day 21 (more )
Note: Double labeled: red - Kcnq4; green - acetylated alpha-tubulin.
Structure Cell Type Level Pattern Image Note
TS28: vestibular ganglion vestibular afferent neuron Present 3C , 3A Coexpressed with acetylated alpha-tubulin in vestibular ganglia neurons.
Specimen 4A/B: postnatal day 8 (more )
Note: Double labeled: red - Kcnq4; green - acetylated alpha-tubulin.
Structure Level Pattern Image Note
TS28: macula of utricle Present 4A/B
Specimen 4C/D: postnatal day 8; Bdnftm3Jae/Bdnftm3Jae, Tg(Pax2-cre)1Akg/0 (more )
Note: Conditional mutant. Double labeled: red - Kcnq4; green - acetylated alpha-tubulin.
Structure Level Pattern Image Note
TS28: macula of utricle Present 4C/D Similar as in the wild-type, although with the reduction as well as disorganization of the neurofibers.
Specimen 4E/F: postnatal day 14; Bdnftm3Jae/Bdnftm3Jae, Tg(Pax2-cre)1Akg/0 (more )
Note: Conditional mutant. Double labeled: red - Kcnq4; green - acetylated alpha-tubulin.
Structure Level Pattern Image Note
TS28: macula of utricle Present 4E/F Similar as in the wild-type, in spite of the complete absences of afferent innervation.
Specimen 4G/H: postnatal day 14; Bdnftm3Jae/Bdnftm3Jae, Tg(Pax2-cre)1Akg/0 (more )
Note: Conditional mutant. Anterior cristae. Double labeled: red - Kcnq4; green - acetylated alpha-tubulin.
Structure Level Pattern Image Note
TS28: crista ampullaris Present 4G/H Similar as in the wild-type, in spite of the complete absences of afferent innervation.
Specimen not shown: postnatal adult; Bdnftm3Jae/Bdnftm3Jae, Tg(Pax2-cre)1Akg/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: macula of saccule Present The pattern of expression in the striolar region of utricles and saccules of mice P35 and older (up to P120) was similar to P21.
TS28: macula of utricle Present The pattern of expression in the striolar region of utricles and saccules of mice P35 and older (up to P120) was similar to P21.
TS28: crista ampullaris Present Widespread Expression extended to the entire sensory epithelium by P35.
Specimen not shown: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: macula of utricle Ambiguous Either absent or barely detectable.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/28/2026
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