About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:342400 Beisel KW, et al., Differential expression of KCNQ4 in inner hair cells and sensory neurons is the basis of progressive high-frequency hearing loss. J Neurosci. 2005 Oct 5;25(40):9285-93
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7548785
Gene symbol: Kcnq4
Gene name: potassium voltage-gated channel, subfamily Q, member 4
Antibody: anti-KCNQ4
Detection system: Secondary antibody coupled to Alexa Fluor
Assay notes: There were no differences observed when using either antiserum alone or in combination.
Results
Specimen 4A1: postnatal day 0 (more )
Note: apical region
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 4A1 No expression in the apical region.
Specimen 4A2: postnatal day 0 (more )
Note: basal hook region
Structure Cell Type Level Pattern Image Note
TS27: organ of Corti cochlear inner hair cell Present 4A2 Expressed in the basal hook region.
TS27: organ of Corti cochlear outer hair cell Present 4A2 Expressed in the basal hook region.
Specimen 4A3: postnatal day 8 (more )
Note: apical region
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 4A3 The developmental upregulation had reached the apical turn.
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 4A3 The developmental upregulation had reached the apical turn.
Specimen 4A4: postnatal day 8 (more )
Note: basal hook region
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present 4A4 The basal hook region showed the adult expression pattern.
TS28: organ of Corti cochlear outer hair cell Present 4A4 The basal hook region showed the adult expression pattern.
Specimen 4A5: postnatal day 21 (more )
Note: apical region
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 4A5 All hair cells, except those in the apical tip, had acquired the adult pattern.
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 4A5 All hair cells, except those in the apical tip, had acquired the adult pattern.
Specimen 4A6: postnatal day 21 (more )
Note: basal hook region
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present 4A6 All hair cells, except those in the apical tip, had acquired the adult pattern.
TS28: organ of Corti cochlear outer hair cell Present 4A6 All hair cells, except those in the apical tip, had acquired the adult pattern.
Specimen 5A: postnatal day 21 (more )
Note: Double labeled: red - Kcnq4; green - Myo7a (assay MGI:7548787).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Graded 5A inset , 5A A basal to apical longitudinal gradients were seen. The inset showed the last vestiges of developmental upregulation of expression in IHCs at the very apical tip.
TS28: organ of Corti cochlear outer hair cell Present Graded 5A inset , 5A A apical to basal longitudinal gradients were seen.
Specimen 5B: postnatal day 21 (more )
Note: Apical region. Double labeled: red - Kcnq4; green - Myo7a (assay MGI:7548787).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear outer hair cell Strong 5B
TS28: organ of Corti cochlear inner hair cell Weak 5B
Specimen 5C: postnatal day 21 (more )
Note: Mid-turn region. Double labeled: red - Kcnq4; green - Myo7a (assay MGI:7548787).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present 5C
TS28: organ of Corti cochlear outer hair cell Present 5C
Specimen 5E/F: postnatal day 21 (more )
Note: Basal hook region. Double labeled: red - Kcnq4; green - Myo7a (assay MGI:7548787).
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear outer hair cell Present 5E , 5F
TS28: organ of Corti cochlear inner hair cell Strong 5E , 5F
Specimen 5I: postnatal day 21 (more )
Note: apical region
Structure Level Pattern Image Note
TS28: cochlear ganglion Strong 5I
Specimen 5L: postnatal day 21 (more )
Note: basal hook region
Structure Level Pattern Image Note
TS28: cochlear ganglion Strong 5L
Specimen 6C P21 Apex: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear outer hair cell Present 6C upper left
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 6C upper left No expression in the apical region.
Specimen 6C P21 Middle: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present 6C upper middle
TS28: organ of Corti cochlear outer hair cell Present 6C upper middle
Specimen 6C P21 Base: postnatal day 21 (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear outer hair cell Weak 6C upper right
TS28: organ of Corti cochlear inner hair cell Strong 6C upper right
Specimen 6C P120 Apex: postnatal day 120 (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Strong 6C lower left
TS28: organ of Corti cochlear outer hair cell Strong 6C lower left
Specimen 6C P120 Middle: postnatal day 120 (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear outer hair cell Present 6C lower middle
TS28: organ of Corti cochlear inner hair cell Strong 6C lower middle
Specimen 6C P120 Base: postnatal day 120 (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear outer hair cell Present 6C lower right
TS28: organ of Corti cochlear inner hair cell Strong 6C lower right
Specimen not shown E18.5: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cochlea Weak Regionally restricted Expressed in the cochlear base, but it was just above background level thresholds.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory