Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | Notes | References

Symbol:	Sellem1(cre/ERT2)Mnz
Name:	selectin, lymphocyte; endonuclease-mediated mutation 1, Michel C Nussenzweig
MGI ID:	MGI:7548487
Synonyms:	SellIRES-CreERT2
Gene:	Sell  Location: Chr1:163889556-163908354 bp, + strand  Genetic Position: Chr1, 71.37 cM
Alliance:	Sellem1(cre/ERT2)Mnz page

Germline Transmission:	Earliest citation of germline transmission: J:342405
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Sellem1(cre/ERT2)Mnz expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Sell (MGI:98279)     Using CRISPR/Cas9 technology IRES-iCreERT2 cassette was inserted in exon 8 of the Sell gene. (J:342405)

Activity:	Tissue activity of this recombinase allele
Driver:	Sell (mouse) Summary of all recombinase alleles driven by Sell. Alliance mouse Sell gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sell Mutation:	41 strains or lines available

Original:	J:342405 Merkenschlager J, et al., Continually recruited naive T cells contribute to the follicular helper and regulatory T cell pools in germinal centers. Nat Commun. 2023 Oct 31;14(1):6944
All:	1 reference(s)