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Gene Expression Data
Assay Details
Assay
Reference: J:342123 Sterling NA, et al., P53 independent pathogenic mechanisms contribute to BubR1 microcephaly. Front Cell Dev Biol. 2023;11:1282182
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7548343
Gene symbol: H2ax
Gene name: H2A.X variant histone
Antibody: anti-gammaH2AX (Ser139) (05-636)
Detection system: Secondary antibody
Results
Specimen 1D WT: embryonic day 14.5 (more )
Note: Double labeled: red - H2ax; red - phospho-histone H3.
Structure Level Pattern Image Note
TS22: cerebral cortex Absent 1D WT (middle) , 1D WT (left) , 1D WT (right)
Specimen 1D BubR1 cKO: embryonic day 14.5; Bub1btm1Jvd/Bub1btm1Jvd, Emx1tm1(cre)Krj/Emx1+ (more )
Note: Conditional mutant. Double labeled: red - H2ax; red - phospho-histone H3.
Structure Level Pattern Image Note
TS22: cerebral cortex Present 1D BubR1 cKO (right) , 1D BubR1 cKO (middle) , 1D BubR1 cKO (left) Significant increase in expression compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory