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Gene Expression Data
Assay Details
Assay
Reference: J:255485 Li S, et al., Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development. Sci Rep. 2017 Oct 18;7(1):13427
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7547159
Gene symbol: Bcl11a
Gene name: BCL11 transcription factor A
Results
Specimen 1a CTIP1: embryonic day 10.5 (more )
Note: Double labeled: red - Bcl11a; green - Krt14 (assay MGI:7547160).
Structure Level Pattern Image Note
TS17: surface ectoderm Present 1a CTIP1:K14 , 1a inset , 1a CTIP1 Expression in single-layered ectoderm, co-localized with Krt14 expression.
TS17: embryo mesoderm Present Regionally restricted 1a CTIP1:K14 , 1a inset , 1a CTIP1 Expression in some dermal cells at early stages from E10.5

Specimen 1b CTIP1: embryonic day 12.5 (more )
Note: Double labeled: red - Bcl11a; green - Krt14 (assay MGI:7547160).
Structure Level Pattern Image Note
TS20: epidermis basal layer Present 1b CTIP1 , 1b CTIP1:K14 , 1b inset Expression co-localized with Krt14 expression.
TS20: dermis Present 1b CTIP1:K14 , 1b inset , 1b CTIP1 Expression in some dermal cells.

Specimen 1c CTIP1: embryonic day 14.5 (more )
Note: Double labeled: red - Bcl11a; green - Krt14 (assay MGI:7547160).
Structure Level Pattern Image Note
TS22: epidermis suprabasal layer Present 1c CTIP1 , 1c CTIP1:K14 , 1c inset Expression in rapidly dividing basal layer.
TS22: dermis Present 1c inset , 1c CTIP1 , 1c CTIP1:K14 Expression in some dermal cells.

Specimen 1d CTIP1: embryonic day 14.5 (more )
Note: Double labeled: red - Bcl11a; green - Krt10 (assay MGI:7547162).
Structure Level Pattern Image Note
TS22: epidermis suprabasal layer Present 1d inset , 1d CTIP1 , 1d CTIP1:K10 Expression in some cells in suprabasal layers, co-localized with Krt10 expression.
TS22: dermis Present 1d CTIP1 , 1d CTIP1:K10 , 1d inset Expression in some dermal cells.

Specimen 1e CTIP1: embryonic day 16.5 (more )
Note: Double labeled: red - Bcl11a; green - Krt14 (assay MGI:7547160).
Structure Level Pattern Image Note
TS24: epidermis basal layer Strong 1e CTIP1:K14 , 1e CTIP1 , 1e inset High level of expression in basal layer, colocalized with Krt14 expression.
TS24: hair bulb Present 1e CTIP1:K14 , 1e CTIP1 , 1e inset
TS24: dermis Present 1e inset , 1e CTIP1:K14 , 1e CTIP1 Expression in some dermal cells.

Specimen 1f CTIP1: embryonic day 16.5 (more )
Note: Double labeled: red - Bcl11a; green - Krt10 (assay MGI:7547162).
Structure Level Pattern Image Note
TS24: epidermis suprabasal layer Weak 1f CTIP1:K10 , 1f CTIP1 , 1f inset Expression in few cells in suprabasal layer.
TS24: dermis Present 1f CTIP1:K10 , 1f inset , 1f CTIP1 Expression in some dermal cells.

Specimen 1g CTIP1: embryonic day 18.5 (more )
Note: Double labeled: red - Bcl11a; green - Krt14 (assay MGI:7547160).
Structure Level Pattern Image Note
TS26: epidermis basal layer Strong 1g inset , 1g CTIP1:K14 , 1g CTIP1 High level of expression in basal layer, colocalized with Krt14 expression.
TS26: hair follicle Present 1g CTIP1:K14 , 1g inset , 1g CTIP1
TS26: dermis Absent 1g CTIP1:K14 , 1g CTIP1 , 1g inset Expression restricted to epidermis.

Specimen 1h CTIP1: embryonic day 18.5 (more )
Note: Double labeled: red - Bcl11a; green - Krt10 (assay MGI:7547162).
Structure Level Pattern Image Note
TS26: epidermis suprabasal layer Present 1h CTIP1 , 1h inset , 1h CTIP1:K10 Expression in few cells in suprabasal layer.
TS26: dermis Absent 1h CTIP1 , 1h inset , 1h CTIP1:K10 Expression restricted to epidermis.

Specimen S1a CTIP1: postnatal week 8 (more )
Note: Double labeled: red - Bcl11a; green - Krt14 (assay MGI:7547160).
Structure Level Pattern Image Note
TS28: epidermis basal layer Present Widespread S1a Expression in majority of cells in basal layer.
TS28: hair follicle Present S1a

Specimen S1b CTIP1: postnatal week 8 (more )
Note: Double labeled: red - Bcl11a; green - Krt10 (assay MGI:7547162).
Structure Level Pattern Image Note
TS28: epidermis suprabasal layer Present S1b Expression in some cells in suprabasal layer.
TS28: hair follicle Present S1b

Specimen S1e CTIP1: embryonic day 18.5 (more )
Note: Double labeled: red - Bcl11a; green - Mki67 (assay MGI:7547165).
Structure Level Pattern Image Note
TS26: epidermis basal layer Present Regionally restricted S1e inset , S1e Some Mki67-expressing proliferating cells did not co-express Bcl11a.

Specimen S2a CTIP1 Ctip1+/+: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: skin Present S2a Ctip1+/+

Specimen S2a CTIP1 Ctip1-/-: embryonic day 18.5; Bcl11atm1.3Leid/Bcl11atm1.3Leid (more )
Structure Level Pattern Image Note
TS26: skin Absent S2a Ctip1-/-

Specimen S2c CTIP1: embryonic day 18.5 (more )
Note: Double labeled: red - Bcl11a; green - Bcl11b (assay MGI:7547166).
Structure Level Pattern Image Note
TS26: epidermis basal layer Present S2c inset , S2c Expression co-localized with Bcl11b in most basal cells.
TS26: epidermis suprabasal layer Present Regionally restricted S2c , S2c inset Some cells of suprabasal layer either Bcl11a-positive or Bcl11b-positive.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory