Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gfraltm1(cre)Vwwt
Name:	GDNF family receptor alpha like; targeted mutation 1, Vicky Wang-Wei Tsai
MGI ID:	MGI:7546840
Synonyms:	Gfral-IRES-cre
Gene:	Gfral  Location: Chr9:76071389-76120939 bp, - strand  Genetic Position: Chr9, 42.48 cM
Alliance:	Gfraltm1(cre)Vwwt page

Germline Transmission:	Earliest citation of germline transmission: J:341053
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Gfraltm1(cre)Vwwt expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gfral (MGI:3607786)     The targeting construct introduced a cre recombinase gene. (J:341053)

Activity:	Tissue activity of this recombinase allele
Driver:	Gfral (mouse) Summary of all recombinase alleles driven by Gfral. Alliance mouse Gfral gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gfral Mutation:	34 strains or lines available

Original:	J:341053 Breit SN, et al., GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway. Cell Metab. 2023 Aug 8;35(8):1341-1355.e3
All:	1 reference(s)