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Dsg1aem1Awar
Endonuclease-mediated Allele Detail
Summary
Symbol: Dsg1aem1Awar
Name: desmoglein 1 alpha; endonuclease-mediated mutation 1, Rajeshwar Awatramani
MGI ID: MGI:7543304
Synonyms: Dsg1-
Gene: Dsg1a  Location: Chr18:20443982-20476407 bp, + strand  Genetic Position: Chr18, 11.29 cM
Alliance: Dsg1aem1Awar page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:320249
Parent Cell Line:  E14TG2a.4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intergenic deletion
 
Mutation details: CRISPR/Cas9 technology deleted exon 2. This allele was generated simultaneously with Dsg1bem1Awar such that exon 2 is deleted in both Dsg1a and Dsg1b. (J:320249)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dsg1a Mutation:  49 strains or lines available
References
Original:  J:320249 Godsel LM, et al., Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor. J Clin Invest. 2022 Feb 1;132(3):e144363
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory