Tg(Prnp-APPSwe,Prnp-PSEN1dE9)D943Dbo
Transgene Detail
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| Symbol: |
Tg(Prnp-APPSwe,Prnp-PSEN1dE9)D943Dbo |
| Name: |
transgene insertion D943, David R Borchelt |
| MGI ID: |
MGI:7541098 |
| Synonyms: |
D-943 |
| Transgene: |
Tg(Prnp-APPSwe,Prnp-PSEN1dE9)D943Dbo Location: unknown Genetic Position: ChrUN, Syntenic
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| Alliance: |
Tg(Prnp-APPSwe,Prnp-PSEN1dE9)D943Dbo page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Prnp-APPSwe,Prnp-PSEN1dE9)D943Dbo expresses
2 genes
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
APP (351) |
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mouse/human chimera with Swedish (K595M/N596L) mutation |
| human |
PSEN1 (5663) |
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exon-9-deleted variant |
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Mutation details: The mouse amyloid beta (A4) precursor protein (App) sequence was first modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (called mo/huAPP695 or APP695) was further mutated to incorporate the Swedish (K595M/N596L) mutation associated with Alzheimer's disease. This APP695Swe/Ind sequence was placed downstream of the brain-specific mouse prion promoter (Prnp). The first transgene was co-integrated with a second transgene in which the mouse prion promoter promoter drives expression of a mutant human presenilin 1 carrying the exon-9-deleted variant (PSEN1dE9) associated with familial Alzheimer's disease.
(J:340366)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:340366 Xu G, et al., Murine Abeta over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathol Commun. 2015 Nov 14;3:72 |
| All: |
2 reference(s) |
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Analysis Tools
