Tg(Camk2a-RAP2A*G12N)2Shng
Transgene Detail
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| Symbol: |
Tg(Camk2a-RAP2A*G12N)2Shng |
| Name: |
transgene insertion 2, Morgan Sheng |
| MGI ID: |
MGI:7540991 |
| Synonyms: |
Rap2N17 |
| Transgene: |
Tg(Camk2a-RAP2A*G12N)2Shng Location: unknown
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| Alliance: |
Tg(Camk2a-RAP2A*G12N)2Shng page
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| Transgene Type: |
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Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Camk2a-RAP2A*G12N)2Shng expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
RAP2A (5911) |
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Expresses a G12N mutation |
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Tg(Camk2a-RAP2A*G12N)2Shng expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Camk2a (MGI:88256) |
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Mutation details: The vector contains the mouse Camk2a promoter directing expression of the human RAP2A (G12N (N12) mutant). Immunohistochemistry and immunoblotting show expression in mouse forebrain (including the hippocampus, cortex, thalamus, striatum, and amygdala).
(J:138992)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:138992 Ryu J, et al., Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction. J Neurosci. 2008 Aug 13;28(33):8178-88 |
| All: |
1 reference(s) |
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Analysis Tools
