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Gene Expression Data
Assay Details
Assay
Reference: J:296266 Ogino H, et al., The Secreted Glycoprotein Reelin Suppresses the Proliferation and Regulates the Distribution of Oligodendrocyte Progenitor Cells in the Embryonic Neocortex. J Neurosci. 2020 Sep 30;40(40):7625-7636
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7539231
Gene symbol: Olig2
Gene name: oligodendrocyte transcription factor 2
Results
Specimen 4A: embryonic day 18.5 (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS26: neocortex Present 4A left
TS26: parietal cortex oligodendrocyte precursor cell Present 4A right , 4A left Primary somatosensory cortex was shown.
Specimen 4B Reln+/+: embryonic day 18.5 (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 4B +/+ Olig2 , 4B +/+ Merge Primary somatosensory cortex was shown.
Specimen 4B Reln+/-: embryonic day 18.5; Relnrl/Reln+ (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 4B +/- Olig2 , 4B +/- Merge Primary somatosensory cortex was shown. Dramatically increased density (approximately a 50% increase), and the distribution markedly shifted toward the superficial layer.
Specimen 4G Dab1+/+: embryonic day 18.5 (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 4G +/+ Merge , 4G +/+ Olig2 Primary somatosensory cortex was shown.
Specimen 4G Dab1+/yot: embryonic day 18.5; Dab1yot/Dab1+ (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 4G +/yot Merge , 4G +/yot Olig2 Primary somatosensory cortex was shown. Dramatically increased density (approximately a 50% increase), and the distribution markedly shifted toward the superficial layer.
Specimen 5A Vldlr+/+: embryonic day 18.5 (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 5A +/+ Olig2 , 5A +/+ Merge Primary somatosensory cortex was shown.
Specimen 5A Vldlr-/-: embryonic day 18.5; Vldlrtm1Her/Vldlrtm1Her (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 5A -/- Olig2 , 5A -/- Merge Primary somatosensory cortex was shown. Increased density by around 50%. The distribution shifted toward the superficial position because the fold change was more prominent in the superficial region (see Fig 5C).
Specimen 6A Adamts3+/+: embryonic day 18.5 (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 6A +/+ Merge , 6A +/+ Olig2 Primary somatosensory cortex was shown.
Specimen 6A Adamts3-/-: embryonic day 18.5; Adamts3tm1b(KOMP)Wtsi/Adamts3tm1b(KOMP)Wtsi (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 6A -/- Olig2 , 6A -/- Merge Primary somatosensory cortex was shown. The number of PDGFRa+Olig2+ cells was significantly decreased compared with the control.
Specimen 6F Reln+/+: embryonic day 18.5 (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 6F +/+ Olig2 , 6F +/+ Merge Primary somatosensory cortex was shown.
Specimen 6F Reln PA-DV/PA-DV: embryonic day 18.5; Relnem1Mhat/Relnem1Mhat (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS26: parietal cortex oligodendrocyte precursor cell Present 6F PA-DV/PA-DV Merge , 6F PA-DV/PA-DV Olig2 Primary somatosensory cortex was shown. The number of PDGFRa+Olig2+ cells was significantly decreased compared with the control.
Specimen 7A Reln+/+: postnatal day 2 (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS27: primary somatosensory cortex oligodendrocyte precursor cell Present 7A +/+ Olig2 , 7A +/+ Merge
Specimen 7A Reln+/-: postnatal day 2; Relnrl/Reln+ (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS27: primary somatosensory cortex oligodendrocyte precursor cell Present 7A +/- Merge , 7A +/- Olig2 The number and position of PDGFRa+Olig2+ cells were not affected.
Specimen 7D Dab1+/+: postnatal day 2 (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS27: primary somatosensory cortex oligodendrocyte precursor cell Present 7D +/+ Merge , 7D +/+ Olig2
Specimen 7D Dab1+/yot: postnatal day 2; Dab1yot/Dab1+ (more )
Note: Double labeled: red - Olig2; green - Pdgfra (assay MGI:7539230).
Structure Cell Type Level Pattern Image Note
TS27: primary somatosensory cortex oligodendrocyte precursor cell Present 7D +/yot Merge , 7D +/yot Olig2 The total number of PDGFRa+Olig2+ cells was slightly increased. The radial distribution was indistinguishable compared with the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
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