Tg(Prnp-CHCHD2)U144Jaaw
Transgene Detail
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| Symbol: |
Tg(Prnp-CHCHD2)U144Jaaw |
| Name: |
transgene insertion U144, Jung-A A Woo |
| MGI ID: |
MGI:7532878 |
| Synonyms: |
CHCHD2-T61IU144 |
| Transgene: |
Tg(Prnp-CHCHD2)U144Jaaw Location: unknown
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| Alliance: |
Tg(Prnp-CHCHD2)U144Jaaw page
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| Strain of Origin: |
Not Applicable
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| Transgene Type: |
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Transgenic (Epitope tag, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The transgene insert contains the murine prion protein promoter and FLAG tag sequence in-frame with human CHCHD2 cDNA with a mutation that changes threonine codon 61(ACC) to isoleucine (ATC) (c.182C>T p.T61I). The mutation is found in some autosomal dominant Parkinson's disease (PD) patients.
(J:340965)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:340965 Kee TR, et al., Pathological characterization of a novel mouse model expressing the PD-linked CHCHD2-T61I mutation. Hum Mol Genet. 2022 Nov 28;31(23):3987-4005 |
| All: |
1 reference(s) |
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Analysis Tools
