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Gene Expression Data
Assay Details
Assay
Reference: J:256718 Shimbo M, et al., Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2. PLoS One. 2017;12(12):e0190333
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7528924
Gene symbol: Acan
Gene name: aggrecan
Antibody: 12/21/1-C-6
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 4D control: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: articular cartilage Present Regionally restricted 4D control bottom , 4D control top There is uniform expression in cartilage extracellular matrix in growth plates.
TS26: tibia Present Regionally restricted 4D control bottom , 4D control top There is uniform expression in cartilage extracellular matrix in growth plates.
Specimen 4D Col2-DKO: embryonic day 18.5; Csgalnact1tm1Nari/Csgalnact1tm1Nari, Csgalnact2tm1.1Staka/Csgalnact2tm1.1Staka, Tg(Col2a1-cre)1Bhr/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: articular cartilage Weak Regionally restricted 4D Col2-DKO top , 4D Col2-DKO bottom In this mutant there were a few positive regions restricted to the periphery of the cartilage lacunae.
TS26: tibia Weak Regionally restricted 4D Col2-DKO top , 4D Col2-DKO bottom In this mutant there were a few positive regions restricted to the periphery of the cartilage lacunae.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory