Gene Expression Data
Assay Details
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Assay
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Reference:
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J:140027
Zou D, et al., Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear. Hum Mol Genet. 2008 Nov 1;17(21):3340-56
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Assay type:
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In situ reporter (knock in)
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MGI Accession ID:
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MGI:7526718
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Gene symbol:
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Eya1
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Gene name:
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EYA transcriptional coactivator and phosphatase 1
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Reporter:
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lacZ
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Direct Detection
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Results
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Specimen
4A:
embryonic day 13.5; Eya1tm1Px/Eya1 +
(more  )
Specimen
4A:
(close  )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Eya1tm1Px/Eya1+
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Age:
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embryonic day 13.5
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Sex:
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Not Specified
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Type:
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section
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Specimen
4B:
embryonic day 13.5; Eya1tm1Px/Eya1 +
(more )
Specimen
4B:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Eya1tm1Px/Eya1+
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Age:
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embryonic day 13.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS21: utricle epithelium |
Present |
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4B
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Expressed throughout the thickness of the epithelia, showed overlapping pattern with Sox2.
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Specimen
4D:
embryonic day 15.5; Eya1tm1Px/Eya1 +
(more )
Specimen
4D:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Eya1tm1Px/Eya1+
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Age:
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embryonic day 15.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS23: vestibular component epithelium |
vestibular hair cell |
Present |
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4D
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Expression became progressively restricted to the differentiating hair cells.
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Specimen
4E:
embryonic day 16.5; Eya1tm1Px/Eya1 +
(more )
Specimen
4E:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Eya1tm1Px/Eya1+
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS24: saccule epithelium |
vestibular hair cell |
Present |
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4E
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Expression became progressively restricted to the differentiating hair cells.
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Specimen
4F:
embryonic day 13.5; Eya1tm1Px/Eya1 +
(more )
Specimen
4F:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Eya1tm1Px/Eya1+
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Age:
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embryonic day 13.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS21: cochlea epithelium |
Present |
Regionally restricted |
4F
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In the more mature basal regions, expressed in the future organ of Corti, but its expression extended into the entire epithelium in the great epithelial ridge.
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Specimen
4H:
embryonic day 14.0; Eya1tm1Px/Eya1 +
(more )
Specimen
4H:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Eya1tm1Px/Eya1+
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Age:
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embryonic day 14.0
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: cochlea epithelium |
Present |
Regionally restricted |
4H
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Expression gradually disappeared in the border cells in the great epithelial ridge adjacent to the future organ of Corti, where the level of Sox2 distribution was gradually increased. Expression remained in the epithelial cells that will give rise to the inner sulcus cells where Sox2 is not expressed.
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Specimen
4L:
embryonic day 14.5; Eya1tm1Px/Eya1 +
(more )
Specimen
4L:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Eya1tm1Px/Eya1+
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS22: cochlea epithelium |
Present |
Regionally restricted |
4L
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Expression gradually disappeared in the border cells in the great epithelial ridge adjacent to the future organ of Corti, where the level of Sox2 distribution was gradually increased. Expression remained in the epithelial cells that will give rise to the inner sulcus cells where Sox2 is not expressed.
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Specimen
4N:
embryonic day 16.5; Eya1tm1Px/Eya1 +
(more )
Specimen
4N:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Eya1tm1Px/Eya1+
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Age:
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embryonic day 16.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS24: greater epithelial ridge |
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Present |
Regionally restricted |
4N
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Expression gradually disappeared in the border cells in the great epithelial ridge adjacent to the future organ of Corti, where the level of Sox2 distribution was gradually increased. Expression remained in the epithelial cells that will give rise to the inner sulcus cells where Sox2 is not expressed.
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| TS24: organ of Corti |
cochlea auditory hair cell |
Strong |
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4N
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| TS24: organ of Corti |
supporting cell of cochlea |
Trace |
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4N
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Almost completely disappeared in the supporting cells.
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Specimen
4P:
postnatal day 2; Eya1tm1Px/Eya1 +
(more )
Specimen
4P:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Eya1tm1Px/Eya1+
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Age:
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postnatal day 2
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Sex:
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Not Specified
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Type:
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section
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Specimen
6M:
embryonic day 9.5; Eya1tm1Px/Eya1 +
(more )
Specimen
6M:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Eya1tm1Px/Eya1+
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Age:
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embryonic day 9.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS15: otocyst |
Present |
Regionally restricted |
6M
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Restricted to the ventral wall.
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Specimen
not shown:
embryonic day 13.5; Eya1tm1Px/Eya1 +
(more )
Specimen
not shown:
(close )
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Genetic Background:
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involves: 129S1/Sv * 129X1/SvJ
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Mutant Allele(s):
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Eya1tm1Px/Eya1+
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Age:
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embryonic day 13.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS21: cochlea epithelium |
Present |
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Expressed in a broad group of cells in the less mature apical region throughout the thickness of the epithelium including the site of the future organ of Corti, and overlapped with Sox2 domain.
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Analysis Tools
