Gene Expression Data
Assay Details
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Assay
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Reference:
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J:140027
Zou D, et al., Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear. Hum Mol Genet. 2008 Nov 1;17(21):3340-56
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:7526712
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Gene symbol:
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Myo7a
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Gene name:
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myosin VIIA
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Results
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Specimen
2H:
embryonic day 18.5; Eya1bor/Eya1 +
(more  )
Specimen
2H:
(close  )
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Genetic Background:
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involves: C3HeB/FeJ
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Mutant Allele(s):
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Eya1bor/Eya1+
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Specimen
2I:
(close )
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Genetic Background:
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involves: C3HeB/FeJ
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Mutant Allele(s):
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Eya1bor/Eya1bor
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: crista ampullaris |
Present |
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2I
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A clear reduction of sensory epithelium and hair cells compared with controls.
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| TS26: utricle epithelium |
Present |
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2I
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A clear reduction of sensory epithelium and hair cells compared with controls.
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Specimen
2J:
(close )
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Genetic Background:
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involves: 129 * C3HeB/FeJ
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Mutant Allele(s):
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Eya1bor/Eya1tm1Rilm
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: crista ampullaris |
Present |
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2J
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Structure could be identifiable by its thickened appearance but was largely reduced in size when compared with normal animals.
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| TS26: utricle epithelium |
Present |
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2J
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Structure could be identifiable by its thickened appearance but was largely reduced in size when compared with normal animals.
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Specimen
2K:
embryonic day 18.5; Eya1bor/Eya1 +
(more )
Specimen
2K:
(close )
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Genetic Background:
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involves: C3HeB/FeJ
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Mutant Allele(s):
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Eya1bor/Eya1+
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Specimen
2L:
(close )
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Genetic Background:
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involves: C3HeB/FeJ
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Mutant Allele(s):
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Eya1bor/Eya1bor
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: saccule epithelium |
Present |
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2L
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A clear reduction of sensory epithelium and hair cells compared with controls.
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Specimen
2M:
(close )
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Genetic Background:
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involves: 129 * C3HeB/FeJ
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Mutant Allele(s):
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Eya1bor/Eya1tm1Rilm
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: saccule epithelium |
Present |
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2M
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Three of five mice (four of 10 ears) showed an extremely small sensory epithelium in the saccule with very few hair cells.
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Specimen
3A:
embryonic day 18.5; Eya1bor/Eya1 +
(more )
Specimen
3A:
(close )
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Genetic Background:
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involves: C3HeB/FeJ
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Mutant Allele(s):
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Eya1bor/Eya1+
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Specimen
3B:
embryonic day 18.5; Eya1tm1Rilm/Eya1 +
(more )
Specimen
3B:
(close )
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Genetic Background:
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involves: 129 * C3HeB/FeJ
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Mutant Allele(s):
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Eya1tm1Rilm/Eya1+
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS26: cochlea epithelium |
cochlear inner hair cell |
Present |
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3B
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Occasional extra inner hair cells were observed in the middle region. No significant changes in hair cell numbers in the basal and middle cochlea.
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Specimen
not shown:
embryonic day 18.5; Eya1tm1Rilm/Eya1 +
(more )
Specimen
not shown:
(close )
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Genetic Background:
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involves: 129 * C3HeB/FeJ
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Mutant Allele(s):
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Eya1tm1Rilm/Eya1+
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS26: cochlea epithelium |
cochlear inner hair cell |
Present |
Regionally restricted |
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In the apical region, many extra hair cells (nearly two rows of inner hair cells) were seen (see Table 2).
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Specimen
3C:
(close )
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Genetic Background:
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involves: C3HeB/FeJ
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Mutant Allele(s):
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Eya1bor/Eya1bor
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Cell Type |
Level |
Pattern |
Image |
Note |
| TS26: cochlea epithelium |
cochlear inner hair cell |
Present |
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3C
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Many extra hair cells were seen, and the rows of hair cells were very disorganized.
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| TS26: cochlea epithelium |
cochlear outer hair cell |
Present |
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3C
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Many extra hair cells were seen, and the rows of hair cells were very disorganized.
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Analysis Tools
