Tg(GP1BA-IL4R/GP1BA)51Ware
Transgene Detail
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| Symbol: |
Tg(GP1BA-IL4R/GP1BA)51Ware |
| Name: |
transgene insertion 51, Jerry Ware |
| MGI ID: |
MGI:7524355 |
| Transgene: |
Tg(GP1BA-IL4R/GP1BA)51Ware Location: unknown
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| Alliance: |
Tg(GP1BA-IL4R/GP1BA)51Ware page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(GP1BA-IL4R/GP1BA)51Ware expresses
2 genes
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
GP1BA (2811) |
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expresses a fusion of the ectodomain of the human IL-4 receptor (residues 1-198 of the mature alpha-subunit of the receptor) and residues 473
to 610 of the human GP Ibalpha mature subunit (GP1BA) |
| human |
IL4R (3566) |
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expresses a fusion of the ectodomain of the human IL-4 receptor (residues 1-198 of the mature alpha-subunit of the receptor) and residues 473
to 610 of the human GP Ibalpha mature subunit (GP1BA) |
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Tg(GP1BA-IL4R/GP1BA)51Ware expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Homolog in Mouse |
Note |
| human |
GP1BA (2811) |
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Mutation details: A DNA construct expressing the ectodomain of the human IL-4 receptor (residues 1-198 of the mature alpha-subunit of the receptor) and residues 473
to 610 of the human GP Ibalpha mature subunit (GP1BA) was inserted downstream of a 3-kb human GP Ibalpha (GP1BA) promoter cassette. Transgenic mouse lines Tg33 and Tg51 express surface fusion protein and were chosen for further studies.
(J:131497)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:131497 Kanaji T, et al., Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome. Blood. 2002 Sep 15;100(6):2102-7 |
| All: |
3 reference(s) |
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Analysis Tools
