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Gene Expression Data
Assay Details
Assay
Reference: J:190998 Yang JW, et al., Autophagy appears during the development of the mouse lower first molar. Histochem Cell Biol. 2013 Jan;139(1):109-18
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7522712
Gene symbol: Map1lc3a
Gene name: microtubule-associated protein 1 light chain 3 alpha
Antibody: anti-LC3
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 2A: embryonic day 13.5 (more )
Note: Bud stage of tooth development.
Structure Level Pattern Image Note
TS21: enamel organ Present 2A
TS21: tooth bud Present 2A
TS21: lower jaw molar mesenchyme Present Regionally restricted 2A Expression is in the condensed mesenchyme underlying the enamel organ.

Specimen 2B: embryonic day 14.5 (more )
Note: Cap stage of tooth development.
Structure Level Pattern Image Note
TS22: cap stage tooth Present 2B
TS22: lower jaw molar enamel organ Present 2B Expression is in the inner and outer enamel epithelium, especially in the cervical loop.
TS22: primary enamel knot Present Regionally restricted 2B Expression is in the part that is facing the mesenchyme.
TS22: lower jaw molar dental papilla Weak 2B
TS22: stellate reticulum Weak 2B

Specimen 2C: embryonic day 16.5 (more )
Note: Early bell stage of tooth development.
Structure Cell Type Level Pattern Image Note
TS24: inner enamel epithelium Present 2C
TS24: outer enamel epithelium Present 2C
TS24: stratum intermedium Present 2C
TS24: lower jaw molar enamel organ Present 2C Expression is in the inner and outer enamel epithelium.
TS24: mandible osteoblast Strong Regionally restricted 2C , 2D Expression is in some of the osteoblasts in the alveolar bone.

Specimen 2E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: secondary palate Very strong Regionally restricted 2E Expression is at the non-transitional epithelial island of the medial epithelial seam at the midline.

Specimen 2F: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: nasal septum Present 2F

Specimen 2G: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: nasal septum Present 2G

Specimen 2H: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: neural retina Strong 2H

Specimen 3A: postnatal day 1.5 (more )
Structure Cell Type Level Pattern Image Note
TS27: molar dental pulp odontoblast Present Regionally restricted 3A , 3B Expression is in polarizing, and differentiated odontoblasts.
TS27: lower jaw molar enamel organ ameloblast Present Regionally restricted 3B , 3A Expression is in the differentiating ameloblasts.
TS27: stellate reticulum Present Single cells 3C , 3A , 3B

Specimen 3D: postnatal day 5.5 (more )
Structure Cell Type Level Pattern Image Note
TS28: lower jaw molar dental follicle Strong 3F , 3D , 3E
TS28: stellate reticulum Strong 3F , 3D , 3E
TS28: stratum intermedium Strong 3F , 3D , 3E
TS28: alveolar process osteoblast Present 3F , 3D , 3E Expression is in osteoblasts in the alveolar bone.
TS28: molar dental pulp odontoblast Present Regionally restricted 3F , 3E , 3D Expression is in odontoblasts.
TS28: lower jaw molar enamel organ ameloblast Present Regionally restricted 3D , 3F , 3E Expression is in ameloblasts.

Specimen 3G: postnatal day 9.5 (more )
Structure Cell Type Level Pattern Image Note
TS28: lower jaw molar dental follicle Strong 3G , 3I , 3H
TS28: stellate reticulum Strong 3G , 3I , 3H
TS28: stratum intermedium Strong 3G , 3I , 3H
TS28: lower jaw molar enamel organ ameloblast Present Regionally restricted 3G , 3H , 3I Expression is in ameloblasts.
TS28: molar dental pulp Present Regionally restricted 3H , 3G , 3I Expression is in odontoblasts.
TS28: alveolar process Present Regionally restricted 3G , 3H , 3I Expression is in osteoblasts in the alveolar bone.
TS28: Hertwig's epithelial root sheath Present 3H , 3G , 3I

Specimen 3J: postnatal day 15.5 (more )
Structure Level Pattern Image Note
TS28: Hertwig's epithelial root sheath Present 3L , 3K , 3J
TS28: periodontal ligament Present 3L , 3K , 3J
TS28: molar dental pulp Present Regionally restricted 3L , 3J , 3K Expression is in odontoblasts.

Specimen not shown: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: inner enamel epithelium Present
TS26: late bell stage tooth Present
TS26: outer enamel epithelium Present
TS26: stratum intermedium Present
TS26: lower jaw molar enamel organ Present Regionally restricted Expression is in the inner and outer enamel epithelium.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory