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Gene Expression Data
Assay Details
Assay
Reference: J:215514 Saulnier A, et al., The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals. Cereb Cortex. 2013 Nov;23(11):2552-67
Assay type: RNA in situ
MGI Accession ID: MGI:7521965
Gene symbol: Wnt8b
Gene name: wingless-type MMTV integration site family, member 8B
Probe: Wnt8b probe
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 4D Dmrt5+/+: embryonic day 12.5 (more )
Note: Double labeled: blue - Wnt8b; brown - Lhx1 (assay MGI:7521979) and Lhx5 (assay MGI:7521980).
Structure Level Pattern Image Note
TS20: cortical hem Present 4D Dmrt5+/+
TS20: diencephalon Present Regionally restricted 4D Dmrt5+/+ Expression was detected in the eminentia thalami.
TS20: telencephalon Present Graded 4D Dmrt5+/+ High-medial to low-lateral graded expression was observed in the dorsomedial telencephalon.
Specimen 4D Dmrt5-/-: embryonic day 12.5; Dmrta2tm1Ejbd/Dmrta2tm1Ejbd (more )
Note: Double labeled: blue - Wnt8b; brown - Lhx1 (assay MGI:7521979) and Lhx5 (assay MGI:7521980).
Structure Level Pattern Image Note
TS20: telencephalon Weak Regionally restricted 4D Dmrt5-/- Dorsomedial telencephalon expression was strongly reduced in the mutant.
TS20: diencephalon Present Regionally restricted 4D Dmrt5-/- Eminentia thalami expression was still detected in the mutant, as shown by co-labeling with the Lhx1/5 marker.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory