Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Cd300cem1(icre,CD2)Cln
Name:	CD300C molecule; endonuclease-mediated mutation 1, Marco Colonna
MGI ID:	MGI:7520352
Synonyms:	CD300cicre-hCD2
Gene:	Cd300c  Location: Chr11:114846931-114851333 bp, - strand  Genetic Position: Chr11, 80.56 cM
Alliance:	Cd300cem1(icre,CD2)Cln page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (Inserted expressed sequence, Recombinase) Mutation:    Insertion   Cd300cem1(icre,CD2)Cln expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human CD2 (914) Cd2  (MGI:88320)   Cd300cem1(icre,CD2)Cln expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Cd300c (MGI:3032626)   Mutation details: the IRES-iCre-P2A-hCD2 construct was inserted after the endogenous Cd300c STOP codon using CRISPR/Cas9 technology. (J:339120)

Activity:	Tissue activity of this recombinase allele
Driver:	Cd300c (mouse) Summary of all recombinase alleles driven by Cd300c. Alliance mouse Cd300c gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd300c Mutation:	12 strains or lines available

Original:	J:339120 Rodrigues PF, et al., pDC-like cells are pre-DC2 and require KLF4 to control homeostatic CD4 T cells. Sci Immunol. 2023 Feb 24;8(80):eadd4132
All:	1 reference(s)