Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(CAG-dreo)Hshu
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Hsien-Sung Huang
MGI ID:	MGI:7516274
Synonyms:	tdTomato-Dre
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(CAG-dreo)Hshu page

Germline Transmission:	Earliest citation of germline transmission: J:338445
Parent Cell Line:	JM8A1.N3 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd

Allele Type:    Targeted (Conditional ready, Recombinase, Reporter) Mutation:    Insertion   Gt(ROSA)26Sortm1(CAG-dreo)Hshu expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note chicken CAG   Mutation details: The targeting vector inserted the CAG promoter, FRT flanked 3XpA, loxP flanked 3XpA, tdTomato-p2A-DreO, and Neo into the Gt(ROSA)26Sor gene via homologous recombination in embryonic stem cells. The removal of both STOP sequences by Flp and Cre recombinase is required to express the tdTomato and DreO recombinase. (J:338445)

Activity:	Tissue activity of this recombinase allele
Driver:	CAG (chicken) Summary of all recombinase alleles driven by CAG.

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:338445 Huang DF, et al., An intersectional genetic approach for simultaneous cell type-specific labelling and gene knockout in the mouse. Development. 2023 Feb 15;150(4):dev201198
All:	1 reference(s)