Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Dmp1tm1(cre)Msue
Name:	dentin matrix protein 1; targeted mutation 1, Makoto Suematsu
MGI ID:	MGI:7513837
Synonyms:	Dmp1-T2A-Cre
Gene:	Dmp1  Location: Chr5:104350479-104361968 bp, + strand  Genetic Position: Chr5, 50.61 cM
Alliance:	Dmp1tm1(cre)Msue page

Germline Transmission:	Earliest citation of germline transmission: J:338540
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Dmp1tm1(cre)Msue expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Dmp1 (MGI:94910)   Mutation details: A T2A-Cre followed by a frt-flanked neo-selection cassette was inserted at the end of the exon 6 into the 3' UTR of the Dmp1 gene by homologous recombination in the ES cells. Western blot analyses indicated Cre recombinase was expressed specifically in bone and tooth with weak expression also in the brain, muscle, and testes. (J:338540)

Activity:	Tissue activity of this recombinase allele
Driver:	Dmp1 (mouse) Summary of all recombinase alleles driven by Dmp1. Comparative matrix view of recombinase activities Alliance mouse Dmp1 gene page

In Mice Carrying this Mutation:

24 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dmp1 Mutation:	42 strains or lines available

Original:	J:338540 Nakamura T, et al., Generation of bicistronic Dmp1-Cre knock-in mice using a self-cleaving 2A peptide. J Bone Miner Metab. 2023 Jul;41(4):470-480
All:	1 reference(s)