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Gene Expression Data
Assay Details
Assay
Reference: J:338018 Stathopoulou A, et al., CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression. Cardiovasc Res. 2023 Apr 13;
Assay type: RNA in situ
MGI Accession ID: MGI:7512994
Gene symbol: Tbx5
Gene name: T-box 5
Results
Specimen 4A,A': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: secondary heart field Present Regionally restricted 4A' , 4A Expression in posterior second heart field.
TS15: heart atrium Present Regionally restricted 4A , 4A' Expression in left ventricle and atria.
TS15: primitive ventricle Present Regionally restricted 4A , 4A' Expression in left ventricle and atria.
Specimen 4B,B': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: secondary heart field Strong Regionally restricted 4B , 4B' Expression increased in posterior second heart field region.
TS15: heart atrium Present 4B , 4B' Expression in heart tube not affected compared to control.
TS15: primitive ventricle Present 4B , 4B' Expression in heart tube not affected compared to control.
Specimen S3G,G': embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: secondary heart field Present Regionally restricted S3G' , S3G Expression in posterior second heart field.
TS15: heart atrium Present Regionally restricted S3G , S3G' Expression in left ventricle and atria.
TS15: primitive ventricle Present Regionally restricted S3G , S3G' Expression in left ventricle and atria.
Specimen S3H,H': embryonic day 9.5; Chd7tm2a(EUCOMM)Wtsi/Chd7tm2a(EUCOMM)Wtsi, Mesp1tm2(cre)Ysa/Mesp1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: secondary heart field Strong Regionally restricted S3H , S3H' Expression increased in posterior second heart field region.
TS15: heart atrium Present S3H' , S3H Expression in heart tube not affected compared to control.
TS15: primitive ventricle Present S3H' , S3H Expression in heart tube not affected compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory