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Mecomtm4(cre/ERT2)Aspe
Targeted Allele Detail
Summary
Symbol: Mecomtm4(cre/ERT2)Aspe
Name: MDS1 and EVI1 complex locus; targeted mutation 4, Archibald Perkins
MGI ID: MGI:7512927
Gene: Mecom  Location: Chr3:30005445-30563937 bp, - strand  Genetic Position: Chr3, 12.66 cM
Alliance: Mecomtm4(cre/ERT2)Aspe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Modified isoform(s), Recombinase)
Mutation:    Insertion
 
Mecomtm4(cre/ERT2)Aspe expression driven by 1 gene
 
Mutation details: Tamoxifen-inducible cre/ERT2 and an FRT-flanked neomycin cassette were introduced to exon 1 of the mouse Mecom gene via homologous recombination in embryonic stem (ES) cells. (J:292941)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mecom (mouse)
Summary of all recombinase alleles driven by Mecom.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mecom Mutation:  81 strains or lines available
Notes
The version of this allele that does not contains the neomycin selection cassette, Mecomtm4.1(cre/ERT2)Aspe, has been analyzed.
References
Original:  J:292941 Christodoulou C, et al., Live-animal imaging of native haematopoietic stem and progenitor cells. Nature. 2020 Feb;578(7794):278-283
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
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