Tg(Thy1-MAPT*P301S)58.4Npa
Transgene Detail
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| Symbol: |
Tg(Thy1-MAPT*P301S)58.4Npa |
| Name: |
transgene insertion 58.4, Novartis Pharma AG |
| MGI ID: |
MGI:7509199 |
| Synonyms: |
Tau58.4, Tau58/4 |
| Transgene: |
Tg(Thy1-MAPT*P301S)58.4Npa Location: unknown
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| Alliance: |
Tg(Thy1-MAPT*P301S)58.4Npa page
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| Strain of Origin: |
C57BL/6 x DBA/2
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Thy1-MAPT*P301S)58.4Npa expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
MAPT (4137) |
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Tau isoform 0N4R containing P301S mutation |
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Tg(Thy1-MAPT*P301S)58.4Npa expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Thy1 (MGI:98747) |
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Mutation details: A MAPT cDNA encoding the human tau isoform (0N4R) containing the P301S mutation is under the control of the neuron-specific murine Thy1.2 promoter.
(J:285139)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:285139 Yin Z, et al., Progressive Motor Deficit is Mediated by the Denervation of Neuromuscular Junctions and Axonal Degeneration in Transgenic Mice Expressing Mutant (P301S) Tau Protein. J Alzheimers Dis. 2017;60(s1):S41-S57 |
| All: |
4 reference(s) |
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Analysis Tools
