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Gene Expression Data
Assay Details
Assay
Reference: J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7507154
Gene symbol: Opn1sw
Gene name: opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)
Antibody: Anti-Blue opsin (AB5407)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen S5G: postnatal month 3; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-. Double labeled: green - Opn1sw; red - peanut agglutinin (PNA).
Structure Cell Type Level Pattern Image Note
TS28: photoreceptor layer retinal cone cell Present S5G The staining was mainly in the segments of the photoreceptors.
Specimen S5H: postnatal month 3; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant. Double labeled: green - Opn1sw; red - peanut agglutinin (PNA).
Structure Cell Type Level Pattern Image Note
TS28: photoreceptor layer retinal cone cell Present Single cells S5H The photoreceptor layer in the mutant was reduced to a few nuclei in a row. Ectopic staining was observed in the cell bodies in the cKO.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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