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Gene Expression Data
Assay Details
Assay
Reference: J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7507064
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-cleaved Caspase3 (asp175)
Detection system: Secondary antibody
Assay notes: Data from this assay was presented in Fig. 8E as a histogram depicting the number of cleaved Casp3-positive cells per square millimeter in control and cKO retina sections.
Results
Specimen P3 Control: postnatal day 3; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-.
Structure Level Pattern Image Note
TS27: neural retina Present Regionally restricted Apoptotic cells were detected in the neuroepithelial layer.
TS27: retina ganglion cell layer Present Apoptotic cells were detected.
Specimen P3 cKO: postnatal day 3; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: neural retina Present Regionally restricted The number of apoptotic cells was increased in the neuroepithelial layer of the cKO compared with the control.
TS27: retina ganglion cell layer Present No significant difference in the number of apoptotic cells was found in the cKO compared with the control.
Specimen P6 Control: postnatal day 6; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-.
Structure Level Pattern Image Note
TS28: neural retina Present Regionally restricted Apoptotic cells were detected in the neuroepithelial layer.
TS28: retina ganglion cell layer Present Apoptotic cells were detected.
Specimen P6 cKO: postnatal day 6; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: neural retina Present Regionally restricted The number of apoptotic cells was decreased in the neuroepithelial layer of the cKO compared to control.
TS28: retina ganglion cell layer Present The number of apoptotic cells was decreased in the cKO compared to control.
Specimen P10 Control: postnatal day 10; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present Apoptotic cells were detected.
TS28: retina inner nuclear layer Present Apoptotic cells were detected.
TS28: retina ganglion cell layer Present Apoptotic cells were detected.
Specimen P10 cKO: postnatal day 10; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present The number of apoptotic cells was increased in the cKO compared with the control.
TS28: retina inner nuclear layer Present No significant difference in the number of apoptotic cells was found in the cKO compared with the control.
TS28: retina ganglion cell layer Present No significant difference in the number of apoptotic cells was found in the cKO compared with the control.
Specimen P15 Control: postnatal day 15; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Ambiguous
TS28: retina inner nuclear layer Ambiguous
TS28: retina ganglion cell layer Ambiguous
Specimen P15 cKO: postnatal day 15; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present The number of apoptotic cells was increased in the cKO compared with the control.
TS28: retina inner nuclear layer Ambiguous
TS28: retina ganglion cell layer Ambiguous
Specimen P21 Control: postnatal day 21; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Ambiguous
TS28: retina inner nuclear layer Ambiguous
TS28: retina ganglion cell layer Ambiguous
Specimen P21 cKO: postnatal day 21; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: retina outer nuclear layer Present The number of apoptotic cells was increased in the cKO compared with the control.
TS28: retina inner nuclear layer Ambiguous
TS28: retina ganglion cell layer Ambiguous
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/24/2026
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